Thirty-five female Sprague-Dawley weanling rats were fed 5-acetamido-3-(5-nitro-2-furyl)-6H-l ,2,4-oxadiazine for 37 weeks. All 32 rats surviving 28 weeks or more developed hemangioendothelialsarcomas at one or more sites. These unusual tumors were located in the livers of 31 rats, in the mesentery of 30 rats, and in the lungs of 5 rats. Nine rats developed alveolar carcinomas, and 1 rat develo...

A detailed electrochemical, photophysical and theoretical study is presented for various new thienyl and furyl derivatives of pyrene. Their optical properties are described based on UV-VIS absorption and both steady-state and time-resolved fluorescence spectroscopy. DFT and TDDFT calculations are also presented to support experimental data. The calculations results show that HOMO-LUMO orbitals ...

A novel series of 3-(2-furyl)acrylate monosaccharide esters Ia–f and menthyloxycarbonyl monosaccharide esters IIa–f were designed and synthesized. The chemical structures of the target compounds were confirmed by IR, ¹H- and ¹³C-NMR and ESI-MS, and the target compounds were investigated for their in vitro antibacterial and antifungal activities. The antibacterial screening results showed that t...

In the title compound, C(13)H(7)NO(4), the 2-furyl ring is essentially planar, with a maximum deviation of 0.004 (1) Å. It is inclined at an angle of 11.69 (4)° to the benzene ring. The nitro group is slightly twisted out of the plane of the 2-furyl ring, with a dihedral angle of 5.72 (8)°. There is a short O⋯C contact of 2.8562 (8) Å (symmetry code: -x, -y, 2 - z). In the crystal packing, mol-...

In the present study 3-(2-Furyl) Propionicacid (C7H8O3) abbreviated as 32FPA which has biological applications had been investigated with Density functional theory calculations with Gaussian 03 software package. The FT-IR, FT-Raman, NMR spectra of the title compound was recorded and analyzed. The equilibrium geometry, bonding features and harmonic vibrational wave numbers were investigated with...

The chiral title compounds, C21H18N2O2, (I), and C21H18N2OS, (II) - products of the three-component reaction between benzyl-amine, isatoic anhydride and furyl- or thienyl-acrolein - are isostructural and form isomorphous racemic crystals. The tetra-hydro-pyrimidine ring in (I) and (II) adopts a sofa conformation. The amino N atom has a trigonal-pyramidal geometry [sum of the bond angles is 347....

The induction of unscheduled DNA synthesis in primary cultures of urothelial cells from rats, mice, and dogs by nitrofurans and arylamines and their derivatives was examined. Electron microscopy of the culture from rat cells showed the characteristics of epithelial cells. The cultured cells were exposed to the test chemicals in a serum-free medium containing 10 mM hydroxyurea and [3H]thymidine ...

synthesis of 4-(n,n- dimethylamino)-3-aryl-3-butene-2-one, ethyl-5-aryl-4-oxo-4h-pyran-2-carboxylate, ethyl-5-aryl-4-pyridones-2-carboxylate and 5-aryl-3-cyano-5-methyl-2-pyridones (aryl=3-thienyl, 2-furyl) are described.