We investigated the effects of iprodione and fludioxonil on the pathogenic yeast Candida albicans. Growth of the wild-type IFO1385 strain of C. albicans was inhibited by both fungicides, while Saccharomyces cerevisiae was basically unaffected by them even at a concentration of 25 microg/ml. Both fungicides stimulated glycerol synthesis in C. albicans but not in S. cerevisiae. The antioxidant al...

In studies on the mode of action of antifuingal agents, it may be valuable to reveal the difference in drug sensitivity between fungal spores and mycelia. Various methods employed in the evaluation of antifungal substances do not necessarily apply to the solution of this problem. For the estimation of "sporostatic" activity of an agent, the inhibitory effect on the course of germination of spor...

BACKGROUND Fenpicoxamid is a new fungicide for control of Zymoseptoria tritici, and is a derivative of the natural product UK-2A. Its mode of action and target site interactions have been investigated. RESULTS UK-2A strongly inhibited cytochrome c reductase, whereas fenpicoxamid was much less active, consistent with UK-2A being the fungicidally active species generated from fenpicoxamid by me...

A rapid decrease of intracellular glutathione (GSH) was observed when exponentially growing cells of Saccharomyces cerevisiae were treated with sublethal concentrations of either dimethyldithiocarbamic acid or thiram [bis(dimethylthiocarbamoyl) disulfide]. The underlying mechanism of this effect possibly involves the intracellular oxidation of dimethyldithiocarbamate anions to thiram, which in ...

Stachybotrys elegans is able to parasitize the fungal plant pathogen Rhizoctonia solani AG-3 following a complex and intimate interaction, which, among others, includes the production of cell wall-degrading enzymes, intracellular colonization, and expression of pathogenic process encoding genes. However, information on the metabolome level is non-existent during mycoparasitism. Here, we perform...

The essential oil extracted from the epicarp of Citrus sinensis exhibited absolute fungitoxicity against soybean’s fungus as Alternaria alternate, Aspergillus niger, Cercospora kikuchii, Chaetomium spp., Cladosporium cladosporioides, Curvularia lunata, Fusarium roseum, Macrophomina phaseolina, Penicillium italicum, Phomopsisspp. Rhizoctonia solani, and Sclerotium rolfsii. It is very difficult t...

Sweet potatoes are important food staples in tropical sub-Saharan Africa. Orange flesh sweet potato (OFSP) varieties especially for combating vitamin A deficiencies and nutrition-induced blindness. Fungal leaf spots one of the many challenges constraining its production Umudike, Southeast, Nigeria. The aims this experiment were to isolate causal fungi OFSP attempt their control using aqueous ex...