The minimal fungicidal concentration (MFC) of dihydrosphingosine (DHS), phytosphingosine (PHS), and five short-chain DHS derivatives was determined for Candida albicans and Candida glabrata. In this respect, a C15- and a C17-homologue of DHS showed a 2- to 10-fold decreased MFC as compared to native DHS (i.e. C18-DHS). DHS derivatives that were active, that is, comprising 12, 15, 17, or 18 carb...

A series of novel glycosylthiadiazole derivatives, namely 2-phenylamino-5-glycosyl-1,3,4-thiadiazoles, were designed and synthesized by condensation between sugar aldehydes A/B and substituted thiosemicarbazide C followed by oxidative cyclization by treating with manganese dioxide. The original fungicidal activities results showed that some title compounds exhibited excellent fungicidal activit...

We have previously reported poor correlation between the in vitro fungicidal activity of LY303366 and MIC results in RPMI medium based upon the manufacturer's suggested susceptibility endpoint, lack of visual growth. Additionally, we have noted a significant trailing effect with LY303366 when MICs are determined in RPMI medium. These observations have led us to evaluate an alternative susceptib...

evaluating the in vitro antifungal activity of phlomis lanceolata, rhynchocorys elephas, otostegia persica and eremurus persicus, four species used in iranian traditional medicine, has been performed on the clinical isolates of the pathogenic fungi aspergillus fumigatus, a. flavus, trichophyton mentagrophytes, t. rubrum, t. verrucosum, microsporum canis, m. gypseum and epidermophyton floccosum ...

Antimicrobial efficacy of flavonoids (free and bound) and crude alkaloids of Lantana camara L. was determined by disc diffusion assay against three bacteria (Escherichia coli, Proteus mirabilis, and Staphylococcus aureus) and two fungi (Candida albicans and Trichophyton mentagrophytes). Minimum inhibitory concentration, minimum bactericidal/fungicidal concentration and total activity were also ...

Some dialkyl alkylphosphonates and dialkyl phenylphosphonates were synthesized by the reactions between trialkyl phosphite and alkyl/aryl halide in the presence of benzene. The synthesized compounds were characterized by elemental analysis, thin layer chromatography (TLC), fourier –transform infrared, ( 1 H, 13 C) nuclear magnetic resonance (NMR) spectroscopic techniques. In vitro fungicidal ac...

1,3,4-Thiadiazole and sugar-derived molecules have proven to be promising agrochemicals with growth promoting, insecticidal and fungicidal activities. In the research field of agricultural fungicide, applying union of active group we synthesized a new set of 1,3,4-thiadiazole xylofuranose derivatives and all of the compounds were characterized by 1H NMR and HRMS. In precise toxicity measurement...

Lippia alba is a plant that has antifungal activity against Aspergillus, Penicillium and Trichoderma genera as well as against human pathogenic microorganisms; however, there are no records on its effect on basidiomycetes which are responsible for white rot of wood. The objective of this study was to evaluate the antifungal activity of L. alba for the control of the white-rot fungus Pleurotus o...

Scedosporium prolificans is a pathogenic mold resistant to current antifungals, and infection results in high mortality. Simultaneous targeting of both ergosterol biosynthesis and heat shock protein 90 (Hsp90) or the calcineurin pathway in S. prolificans may be an important strategy for enhancing the potency of antifungal agents. We hypothesized that the inactive triazoles posaconazole (PCZ) an...

This study was conducted to investigate the antifungal potential and cytotoxicity of selected medicinal plants from Malaysia. The extracts from the stem of Cissus quadrangularis and the leaves of Asplenium nidus, Pereskia bleo, Persicaria odorata and Sauropus androgynus were assayed against six fungi using p-iodonitrotetrazolium-based on colorimetric broth microdilution method. All the plant ex...