Dual targeting is an important and abundant phenomenon. Indeed, we estimate that more than a third of the yeast mitochondrial proteome is dual localized. The enzyme fumarase is a highly conserved protein in all organisms with respect to its sequence, structure, and enzymatic activity. In eukaryotes, it is dual localized to the cytosol and mitochondria. In Saccharomyces cerevisiae, the dual loca...

lentinan a polysaccharide from medicinal mushroom i.e lentinus, has been known to have anticancer properties. telomerase activity is not observed in normal healthy cells, whereas in cancerous cells telomerase expression is high. telomerase represents a promising cancer therapeutic target. we investigated the inhibitory effect of lentinan on telomerase reverse transcriptase gene (htert) which is...

lentiviral vectors are promising gene delivery tools capable of transducing a variety of dividing and non-dividing cells, including pluripotent stem cells which are refractory for transduction by murine retroviruses. although there is a growing debate on the safety of lentiviral vectors for gene transfer, in particular for those derived from human immunodeficiency viruses, type one (hiv-1) and ...

abstract background: schizophrenia is a severe mental disorder and numerous genes and loci are beleived to be involved in this disease. recent studies have reported a strong genetic association between dtnbp1 (dystrobrevin-binding protein 1) gene variants and schizophrenia. methods: in this research, we used a case-control study to establish the possible association between the p1635 (rs3213207...

the engineering of transgenic canola (brassica napus l. ) to make tolerance to the broad-spectrum herbicide, glyphosate, is one of the most effective approaches for weed management. glyphosate inhibits the enzyme epsps (5-enolpyruvylshikimate-3-phosphate synthase) enzyme which functions in the shikimate pathway and has a key role in biosynthesis of aromatic amino acids required for survival of ...

this study was performed to investigate two polymorphic sites from cyp19 gene (pvuii and mspi) and one polymorphic site from erα gene (snabi) in four cattle breeds including mazandarani, taleshi, sistani and simmental. in overall 278 samples for cyp19 and 206 samples for erα marker sites were genotyped using polymerase chain reactionsingle-strand conformation polymorphism (pcr-rflp) procedure. ...

suicide is a major public health concern, with approximately one million people committing suicide world-wide each year .risk factors for suicidal behavior include, psychiatric and medical illness, impulsivity, aggression, alcohol and drug abuse specially stimulants, and  stress. neurobiological, brain mappings and biochemical studies have revealed that suicide victims experiencing a large numb...

background: molecular diversity of leishmania major and its morphological changes have become a controversial issue among researchers. some aspects of polymorphic shapes of amastigotes in clinical manifestations along with molecular variation were evaluated among suspected patients of some exceptional zoonotic cutaneous leishmaniasis locations in northern khuzestan, southwestern iran. methods: ...