BACKGROUND AND AIMS Polymorphisms in the first intron of FTO have been robustly replicated for associations with obesity. In the Sorbs, a Slavic population resident in Germany, the strongest effect on body mass index (BMI) was found for a variant in the third intron of FTO (rs17818902). Since this may indicate population specific effects of FTO variants, we initiated studies testing FTO for sig...

Plasmon-assisted energy conversion is investigated in a comparative study of dye-sensitized solar cells (DSCs) equipped with photo-anodes, which are fabricated by forming gold (Au) and silver (Ag) nanoparticles (NPs) on an fluorine-doped tin oxide (FTO) glass surface by means of dry plasma reduction (DPR) and coating TiO₂ paste onto the modified FTO glass through a screen printing method. As a ...

Copper nanoparticles/fluorine-doped tin oxide (FTO) nanocomposites were successfully prepared by a simple hydrothermal method. The synthesized nanocomposites were characterized by X-ray diffraction (XRD), UV-visible diffuse-reflectance spectrum (UV-VIS DRS), energy dispersive X-ray (EDX), transmission electron microscopy (TEM), Raman spectra, and X-ray photoelectron spectroscopy (XPS). The obta...

The highly regulated differentiation and proliferation of pre-adipocytes play a key role in the initiation of obesity. Fat mass and obesity associated (FTO) is a novel gene strongly associated with the risk of obesity. A deficiency of FTO may cause growth retardation in addition to fat mass and adipocyte size reduction in vivo. To investigate the potential role of Fto gene on the proliferation ...

SNPs (single nucleotide polymorphisms) on a chromosome 16 locus encompassing FTO, as well as IRX3, 5, 6, FTM and FTL are robustly associated with human obesity. FTO catalyses the Fe(II)- and 2OG-dependent demethylation of RNA and is an AA (amino acid) sensor that couples AA levels to mTORC1 (mammalian target of rapamycin complex 1) signalling, thereby playing a key role in regulating growth and...

Beckman Institute and Division of Chemist Institute of Technology, Pasadena, Californ edu † Electronic supplementary informatio photoanode performances; experimental FTO-glass photoanodes; statistics of aspect-ratio-normalised diameter distrib FTO-glass photoanodes; effect of iodi solubility of metal salts in the spin-coat of electrodeposited BiVO4 without sulte spectrum; SEM images of FTO on ...

Variations in the fat mass and obesity-associated (FTO) gene are linked to obesity. However, the underlying neurobiological mechanisms by which these genetic variants influence obesity, behavior, and brain are unknown. Given that Fto regulates D2/3R signaling in mice, we tested in humans whether variants in FTO would interact with a variant in the ANKK1 gene, which alters D2R signaling and is a...

N6-methyladenosine (m6A) is the most abundant base modification found in messenger RNAs (mRNAs). The discovery of FTO as the first m6A mRNA demethylase established the concept of reversible RNA modification. Here, we present a comprehensive transcriptome-wide analysis of RNA demethylation and uncover FTO as a potent regulator of nuclear mRNA processing events such as alternative splicing and 3΄...

Common variants of human fat mass- and obesity-associated gene Fto have been linked with higher body mass index, but the biological explanation for the link has remained obscure. Recent findings suggest that these variants affect the homeobox protein IRX3. Here we report that FTO has a role in white adipose tissue which modifies its response to high-fat feeding. Wild type and Fto-deficient mice...

OBJECTIVE To investigate potential functional variants in FTO and SH2B1 genes among Chinese children with obesity. METHODS Sanger sequencing of PCR products of all FTO and SH2B1 exons and their flanking regions were performed in 338 Chinese Han children with obesity and 221 age- and sex-matched lean controls. RESULTS A total of seven and five rare non-synonymous variants were identified in ...