نتایج جستجو برای: fsh receptor

تعداد نتایج: 597282  

Journal: :Biology of reproduction 2000
B Sommersberg A Bulling U Salzer U Fröhlich R E Garfield A Amsterdam A Mayerhofer

Follicle-stimulating hormone is the major regulator of growth and development of antral follicles in the ovary. Granulosa cells (GCs) in these follicles are coupled via gap junctions (GJs) consisting of connexin 43 (Cx 43). Because we and others have found that Cx 43 and GJs, respectively, are more abundant in large antral follicles compared with small antral and preantral follicles, we hypothe...

Journal: :The Journal of endocrinology 2005
Fu-Qing Yu Chun-Sheng Han Wei Yang Xuan Jin Zhao-Yuan Hu Yi-Xun Liu

In the present study, we started out to test whether the follicle-stimulating hormone (FSH)-activated p38 MAPK signaling cascade was involved in the regulation of steroidogenesis in granulosa cells (GCs). GCs were prepared from the ovaries of DES-treated immature rats and cultured in serum-free medium. Treatment of GCs with FSH (50 ng/ml) induced the phosphorylation of p38 MAPK rapidly with the...

Journal: :Frontiers in bioscience 2010
Cui-hong Fan Cui-Ling Lu Jun-Ling Yang Xiao-Qian Hu Yu Ren Huan Cai Min Chen Zhao-Yuan Hu Fei Gao Yi-Xun Liu

Gonadotrophin-releasing hormone type 1 and type 2 have been demonstrated to inhibit follicle-stimulating hormone (FSH)-induced granulosa cell (GC) steroidogenesis. A third type of GnRH (GnRH-III) was also purified from salmon, its action on the FSH-regulated GC function, however is not clear. In the present study we demonstrated that the FSH-induced estrogen and progesterone production in cultu...

Journal: :Molecular human reproduction 2002
Satoko Sudo Masataka Kudo Shin-ichiro Wada Osamu Sato Aaron J W Hsueh Seiichiro Fujimoto

To determine the influence of FSH receptor variants Thr307-Asn680 (TN) and Ala307-Ser680 (AS) on ovarian function, we investigated the frequency of these gene polymorphisms by using restriction fragment length polymorphism analysis and observed their effects on clinical manifestations. In a population of 522 Japanese women, the overall frequency of TN/TN (NN), TN/AS (NS), and AS/AS (SS) was 41....

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2012
Xuliang Jiang Heli Liu Xiaoyan Chen Po-Han Chen David Fischer Venkataraman Sriraman Henry N Yu Steve Arkinstall Xiaolin He

FSH, a glycoprotein hormone, and the FSH receptor (FSHR), a G protein-coupled receptor, play central roles in human reproduction. We report the crystal structure of FSH in complex with the entire extracellular domain of FSHR (FSHR(ED)), including the enigmatic hinge region that is responsible for signal specificity. Surprisingly, the hinge region does not form a separate structural unit as wide...

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2010
Joseph G Cannon Miriam Cortez-Cooper Eric Meaders Judith Stallings Sara Haddow Barbara Kraj Gloria Sloan Anthony Mulloy

Recent studies have indicated that follicle-stimulating hormone (FSH) promotes bone loss. The present study tested the hypothesis that FSH enhances the activity of bone-resorbing cytokines [interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha, and IL-6], either by inducing their secretion or by altering their receptor expression. Thirty-six women between the ages of 20 and 50 were assessed...

2015
Jie Wang Wenwen Zhang Chunxiao Yu Xu Zhang Haiqing Zhang Qingbo Guan Jiajun Zhao Jin Xu Ferenc Gallyas

OBJECTIVE The objectives of this study were to observe the changes in follicle-stimulating hormone (FSH) and bone mineral density (BMD) in postmenopausal women, to research the relationship between FSH and postmenopausal osteoporosis, and to observe the effects of FSH on osteoclast differentiation in RAW264.7 cells. METHODS We analyzed 248 postmenopausal women with normal bone metabolism. A r...

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