Pharmaceutical tablets ingested orally remain the most popular dosage form in drug delivery, while frequently used route for administration of therapeutic agents remains oral route. Recently, excipient development comprising a mixture two or more materials assembled single frame by means particle engineering, known as co-processed excipients, has gained enormous popularity. To prepare ibuprofen...

THE CASE with apoplectic attacks described by Robert Adams (1827) and also one of the cases reported by Stokes (1846), had yellow discolouration and friability of the left ventricular wall, almost certainly had organising myocardial infarcts. Recently Davies et al (1967) studied the histology of the conducting tissue in fourteen cases with complete heart block complicating myocardial infarction...

Background: Artemether (ARTM) under Biopharmaceutical Classification System (BCS), is a class IV drug, due to its poor water solubility and permeability. It very effective against acute severe forms of falciparum malaria, thus the need improve short half-life. Objective: To enhance dissolution rate ARTM by preparation solid dispersions using solvent evaporation method. Materials method: The dis...

The aim of this study is to evaluate the adhesion ability of okra gum, which is gaining popularity as a tablet binder. For this purpose, gum was extracted from okra pods, and the binding strength of different concentrations (1%, 3%, and 5%) was determined quantitatively. Additionally, naproxen sodium tablets were prepared by using okra gum as a binder and were evaluated for their properties inc...

Objective: The aim of this work was preparing once daily fast disintegrating tablets to handle easily for adult hypertensive patients who have difficulty in swallowing. Methods: Solid dispersions bisoprolol hemifumarate (SD-BH) was prepared by using EC and HPMC in different ratios. A 3* 22 full factorial design was used to investigate the main formulation parameters (different fillers, binder d...

The present study was designed to study drug release retardant property of myrrh oleo-gum resin from tablets prepared by direct compression method (without binding agent). The tablets were evaluated for various physical tests viz. hardness, friability, tensile strength and drug content. Accelerated stability testing was carried out according to ICH guidelines. Batch F-VII showed 041% friability...

The objective of the present study is to develop a pharmaceutically stable, cost effective and quality improved robust formulation of Valsartan Immediate Release tablets. The aim of work is related to the formulation and evaluation of 10mg of dispersible tablet. Valsartan belongs to a class of antihypertensive agents called angiotensin II receptor blockers (ARBs). Total nine formulations were p...

Rosuvastatin is a Dyslipidaemic Agents, which acts by inhibition of HMG-CoA reductase enzyme. Used in the treatment of hyperlipidemia. Therefore the present investigation was to design a formulation of orally disintegrating tablets of Rosuvastatin. Orally disintegrating tablets of Rosuvastatin were formulated by Superdisintegrant addition method by direct compression technique. All the fourteen...

Pharmaceutical Manufacturing is an important enterprise and oral tablet manufacturing is the most significant of all, because more drugs are made as tablets than any other dosage form. The way of tablet manufacturing has been undergoing change in recent years and is likely to head in new directions. In this study Tinospora cordifolia (guduchi) a freely available, a climbing shrub belonging to t...

Squamous cell carcinoma is a common cancer to the head and neck region that is typically diagnosed when it is 2 cm in size. This case report illustrates a patient who had neglected an auricular carcinoma for over a year. At the time of presentation the entire ear was infected with pseudomonas and yeast and chronic friability and bleeding caused an anemia which required blood transfusion.