background : primary central nervous system involvement and central nervous system relapse are poor prognostic events in acute lymphoblastic leukemia. due to severe skeletal and endocrine complications of craniospinal radiotherapy, only cranial radiotherapy is advisable. however only 15% of the cases with central nervous system relapse may remain in remission; a second central nervous system or...

ObjectiveTo synthesize the evidence on Sertoli–Leydig cell tumour (SLCT) relapses, and identify clinicopathological characteristics prognosis of patients with recurrent SLCT.MethodsA literature search was undertaken all published cases SLCT relapse found in PubMed, Embase Web Science databases between January 1998 2021. All articles English reporting at least one case mentioning location or fol...

The aim of the present study was to report clinical, radiological and bronchoalveolar lavage (BAL) findings in patients with pulmonary manifestations of HIV-associated multicentric Castleman's disease (MCD). This was a retrospective study of 12 patients with histologically proven MCD. Clinical manifestations were as follows: dyspnoea (nine out of 12 cases), cough (n = 10), bilateral crackles (n...

The maintenance of chronic immune activation due to leishmaniasis or even due to microbial translocation is associated with immunosenescence and may contribute to frequent relapses. Our aim was to investigate whether patients with HIV-associated visceral leishmaniasis (VL/HIV) who experience a single episode of VL have different immunological behaviors in comparison to those who experience freq...

INTRODUCTION The idiopathic inflammatory myopathies are systemic autoimmune diseases characterized by chronic muscle inflammation resulting progressive weakness and frequent involvement of internal organs, mainly the pulmonary, gastrointestinal and cardiac systems. OBJECTIVE To present clinical characteristics, disease course, frequency of relapses and survival of 79 patients with juvenile or...

Nephrotic syndrome (NS) refers to the constellation of massive proteinuria, hypoalbuminemia, generalized oedema and hyper lipidemia due to failure of the glomerular filtration barrier [1]. The syndrome in children is commonly caused by either of two idiopathic diseases: minimal-changenephropathy (MCN) and focal segmental glomerulosclerosis (FSGS) [1]. According to a report by the International ...

We studied the clinical and evolution characteristics of multiple sclerosis (MS) patients followed since the onset of HUCFF/UFRJ in 1978. The diagnosis of MS was based on Poser's et al. and MC Donald's et al. criteria. From 188 patients, 122 were included. Eighty-five were females. The mean age onset was 32.2 years-old (range 6.0 to 61.0+/-10.3), mainly Caucasians (82/67%). The relapsing-remitt...

Dermatitis neglecta (DN) is a condition that arises secondary to inadequate cleansing and self-neglect leading the accumulation of epidermal debris, corneocytes sebum. Rarely reported, it often diagnostically challenging can mimic other pathologies. It typically in cases chronic disability or psychiatric illness. We present case 72-year-old lady with extensive hyperkeratotic plaques vulva. Init...