Introduction: Application of low-frequency stimulation (LFS) is a new method for treatment of drug resistant epileptic patients. Previous studies demonstrated that activation of receptors coupled to Gi proteins is one of the mechanisms of the anticonvulsant effect of LFS. Thus, in this study, alterations in the expression of RGS4 and RGS10 proteins, as negative regulators of Gi proteins, wer...

Objective(s):To determine the effect of acetylcholine (ACh), pilocarpine, and atropine on pain evoked responses of pain excited neurons (PEN) and pain inhibited neurons (PIN) in hippocampal CA3 region of morphine addicted rats. Materials and Methods:Female Wistar rats, weighing between 230-260 g were used in this study. Morphine addicted rats were generated by subcutaneous injection of increasi...

OBJECTIVE To determine whether the plastic changes induced in human motor cortex by afferent stimulation depend on stimulus frequency. METHODS Transcranial magnetic stimulation was used to examine changes in corticospinal excitability in 20 subjects before and after combined peripheral (motor point) and central stimulation. Peripheral stimuli were given as either low frequency (3 Hz) or high ...

Abstract There is evidence that high-frequency transcranial random noise stimulation (hf-tRNS) effective in improving behavioural performance several visual tasks. However, so far there has been limited research into the spatial and temporal characteristics of hf-tRNS-induced facilitatory effects. In present study, electroencephalogram (EEG) was used to investigate dynamics cortical activity mo...

Schiller Y, Bankirer Y. Cellular mechanisms underlying antiepileptic effects of lowand high-frequency electrical stimulation in acute epilepsy in neocortical brain slices in vitro. J Neurophysiol 97: 1887–1902, 2007. First published December 6, 2006; doi:10.1152/jn.00514.2006. Approximately 30% of epilepsy patients suffer from drug-resistant epilepsy. Direct electrical stimulation of the epilep...

Introduction: The nucleus accumbens is involved in various functions ranging from motivation and reward to feeding and drug addiction. Some researchers have also suggested that this region has some roles in consciousness. In the present study, the effect of electrical stimulation and lesion of nucleus accumbens on Electroencephalogram waves (EEG) of addict and non-addict rats was investigated. ...