OBJECTIVES To operationalize and compare three models of frailty, each representing a distinct theoretical view of frailty: as deficiencies in function (Functional Domains model), as an index of health burden (Burden model), and as a biological syndrome (Biologic Syndrome model). DESIGN Cross-sectional analysis. SETTING 2004 wave of the Health and Retirement Study, a nationally representati...

Objective: To find out if decreased grip strength is associated with frailty and adverse outcomes at three-month follow-up. Materials methods: A descriptive, observational prospective study. Patients older than 59 years of age attending a day hospital were included in the research. The dominant hand was measured during an outpatient visit. Frailty assessed using Edmonton Frail Scale. associatio...

There is a need for interventions to reduce frailty in older people with Alzheimer's dementia (AD). The purpose of this study was investigate the effect home-based multimodal exercise program adults AD (AD-HOMEX) on frailty. A parallel single-blind randomized controlled trial comparing and usual care. Brazil. Forty individuals aged 65 years or mild moderate AD. intervention group (IG) participa...

Abstract Background Frailty is associated with significant morbidity and mortality among elderly adults. Whether frailty predicts adverse outcomes in patients treated oral anticoagulants for stroke prevention atrial fibrillation remains uncertain. Purpose To examine the impact of clinical non-valvular edoxaban. Methods This an observational prospective single centre cohort study enrolling conse...

OBJECTIVES Despite the rapidly increasing prevalence of cohabitation among older adults, the caregiving literature has exclusively focused on formally married individuals. Extending prior work on intra-couple care, this study contrasts frail cohabitors' patterns of care receipt from a partner to that of frail spouses. METHODS Using nationally representative panel data from the Health and Reti...

BACKGROUND Primary care-based comprehensive care programs have the potential to improve outcomes in frail older adults. We evaluated the impact of the Geriatric Care Model (GCM) on the quality of life of community-dwelling frail older adults. METHODS A 24-month stepped wedge cluster randomized controlled trial was conducted between May 2010 and March 2013 in 35 primary care practices in the N...

BACKGROUND Evidence suggests a possible bidirectional connection between cardiovascular disease (CVD) and the frailty syndrome in older people. PURPOSE To verify the relationship between CVD risk factors and the frailty syndrome in community-dwelling elderly. METHODS This population-based study used data from the Fragilidade em Idosos Brasileiros (FIBRA) Network Study, a cross-sectional stu...

BACKGROUND Circulating myeloid cells are important mediators of the inflammatory response, acting as a major source of resident tissue antigen presenting cells and serum cytokines. They represent a number of distinct subpopulations whose functional capacity and relative concentrations are known to change with age. Little is known of these changes in the very old and physically frail, a rapidly ...