INTRODUCTION: The molecular and cellular regulation of fracture healing is not completely understood, yet such knowledge is critical to developing treatments to optimize bone repair and remodeling. One area of continued interest is osteoimmunology: studying the interactions between pathways of the immune system and their interplay with bone healing. Specifically, immunological regulation of the...

nt matter & 2007 007.08.001 thor. [email protected] Summary Fracture healing is a complex and well orchestrated regenerative process, initiated in response to injury, resulting in optimal skeletal repair and restoration of skeletal function. Fracture healing remains to a great extent an unknown cascade, and recent developments in molecular biology have helped us to better understand the fractu...

Bone fractures are one of the leading causes of emergency room visits worldwide, with approximately 8 million bony fractures occurring annually in the US alone. Although the majority of fractures do not cause significant long-term morbidity and mortality, approximately 10% of these fractures result in impaired fracture healing, drastically affecting quality of life in affected patients. By incr...

INTRODUCTION Open crus fracture is still difficult in clinical treatment because of the delayed fracture union and high rate of nonunion after the operation. A consensus has been reached that mechanical stress can promote fracture healing. We independently developed a stress stimulator, which can provide longitudinal pressure for the fixed fracture end of the lower legs to promote fracture heal...

BACKGROUND The overexpression of tumor necrosis factor (TNF)-α leads to systemic as well as local loss of bone and cartilage and is also an important regulator during fracture healing. In this study, we investigate how TNF-α inhibition using a targeted monoclonal antibody affects fracture healing in a TNF-α driven animal model of human rheumatoid arthritis (RA) and elucidate the question whethe...

OBJECTIVES Small animal models of fracture repair primarily investigate indirect fracture healing via external callus formation. We present the first described rat model of direct fracture healing. METHODS A rat tibial osteotomy was created and fixed with compression plating similar to that used in patients. The procedure was evaluated in 15 cadaver rats and then in vivo in ten Sprague-Dawley...

The failure of an osseous fracture to heal (development of a non-union) is a common and debilitating clinical problem. Mice lacking the tumor suppressor Pten in osteoblasts have dramatic and progressive increases in bone volume and density throughout life. Since fracture healing is a recapitulation of bone development, we investigated the process of fracture healing in mice lacking Pten in oste...

The purpose was to detect the effects of ovariectomy (OVX) on femoral fracture healing through different angiogenesis and HIF-1α expression in mice. Thirty-six young female C57 mice were randomized into two groups: OVX and age-matched intact control (CON). The femoral fracture was generated at 3 weeks after OVX or CON. At 2 or 4 weeks after fracture, the femoral fracture area was evaluated heal...

Introduction Fracture healing can be defined as the physiological restoration of bone tissue, structure and function. A common association seen in orthopaedic practice is accelerated fracture healing, with exuberant callus formation in patients, with concomitant head injuries. This review explores our current state of understanding of this relationship. Materials and methods EMBASE and MEDLINE ...

Fracture treatment is an old endeavour intended to promote bone healing and to also enable early loading and regain of function in the injured limb. However, in today's clinical routine the healing potential of the initial fracture haematoma is still not fully recognized. The Arbeitsgemeinschaft für Osteosynthesefragen (AO) formed in Switzerland in 1956 formulated four AO principles of fracture...