BACKGROUND Small drifts in intracoronary pressure measurements (±2 mm Hg) can affect stenosis categorization using pressure indices. This has not previously been assessed for fractional flow reserve (FFR), instantaneous wave-free ratio (iFR), and whole-cycle distal pressure/proximal pressure (Pd/Pa) indices. METHODS AND RESULTS Four hundred forty-seven stenoses were assessed with FFR, iFR, an...

BACKGROUND Fractional flow reserve (FFR) and coronary blood flow velocity reserve (CFR) represent physiological quantities used to evaluate coronary lesion severity and to make clinical decisions. A comparison between the outcomes of both diagnostic techniques has not been performed in a large cohort of patients with intermediate coronary lesions. METHODS AND RESULTS FFR and CFR were assessed...

Fractional flow reserve (FFR)-guided percutaneous intervention is superior to standard assessment but remains underused. The authors have developed a novel "pseudotransient" analysis protocol for computing virtual fractional flow reserve (vFFR) based upon angiographic images and steady-state computational fluid dynamics. This protocol generates vFFR results in 189 s (cf >24 h for transient anal...

Background Fractional flow reserve (FFR) is an invasive procedure evaluating the functional significance of an intermediate stenosis by measurement of pressure drop across stenosis [1]. Noninvasive pressure measurement technique i.e. Phase-contrast (PC)-MRI has been studied in the cardiac chamber[2], aorta[3], and renal[4] arteries. The purpose of this study was to investigate the feasibility o...

BACKGROUND The assessment of functional coronary lesion severity using intracoronary physiological parameters such as coronary flow velocity reserve and the more widely used fractional flow reserve relies critically on the establishment of maximal hyperemia. We evaluated the diagnostic accuracy of the stenosis resistance index during nonhyperemic conditions, baseline stenosis resistance index, ...

Abstrakt.....................................................................................................................3 Introduction...............................................................................................................................5 Publication 1: Improvement of fractional flow reserve and collateral flow by treatment with external counterpulsation(Art. Net.2 ...

OBJECTIVES This study sought to assess the impact of a wide range of mean right atrial pressure (Pra) on fractional flow reserve (FFR) measurements. BACKGROUND FFR invasively assesses the ischemic potential of coronary stenoses. FFR is calculated as the ratio of mean distal coronary pressure (Pd) to mean aortic pressure (Pa) during maximal hyperemia. The Pra is considered to have little impac...

and at 6 months follow-up. As in other studies, there was only moderate correlation between coronary flow velocity reserve and diameter stenosis in lesions of moderate severity and the cut-off of coronary flow velocity reserve was 1·9 for patients with intermediate lesions. There are some known limitations with the use of Doppler coronary flow velocity reserve determinations. To obtain a good s...

Little doubt exists about the outcome benefit of an invasive strategy in patients with an acute coronary syndrome (ACS). Yet, once the revascularization is performed, the treatment strategy of patients admitted with an ACS is not always as straightforward in daily clinical practice as indicated in guidelines. The reasons for this are at least three-fold. First, a sizable proportion of patients ...

Fractional flow reserve (FFR) has become an increasingly important index for decision making with respect to revascularization of coronary artery stenosis. It is the gold standard to indicate whether a particular stenosis is responsible for inducible ischemia and it is generally accepted that a stenosis with an ischemic value of FFR is responsible for angina pectoris and a worse outcome, and sh...