The identification of isomeric drugs is gaining increasing importance in forensics and doping control. Isomers vary terms safety, effectiveness, regulation, particularly for amphetamine-related (ARDs). This study developed validated a pseudo-isocratic UPLC-qTOF-MS analytical method the Amphetamine-related (ARDs) blood following mixed-mode solid-phase extraction (MMSPE). procedure requires 250 ?...

QuEChERS stands for Quick, Easy, Cheap, Effective, Rugged, and Safe. This method is widely used to determine pesticides and was first introduced in 2003. Anastassiades and colleagues first introduced this method in 2003 to extract veterinary drugs from animal tissue [1]. Toxicology samples in forensic medicine are usually analyzed by Liquid-Liquid extraction (LLE) and solid phase extraction (SP...

Medical management, is a team work and the nature of clinical toxicology is multidisciplinary. Internal organs problems following intoxications are included in field of internal medicine; similar problems in poisoned children brings pediatric medicine into the arena. The emergency nature of many acute intoxications, the legal problems of poisoned patients, respiratory assist in unconscious case...

The current status of forensic toxicology in the United Kingdom is discussed with an emphasis on professional training and development. Best practice is proposed using a blend of modular foundation knowledge training, continuing professional development, academic study, research & development and ongoing analytical practice. The need for establishing a professional career structure is also disc...

The principles and procedures employed in a modern forensic toxicology lab are detailed in this review. Aspects of Behavioral and Postmortem toxicology, including certification of analysts and accreditation of labs, chain of custody requirements, typical testing services provided, rationale for specimen selection, and principles of quality assurance are discussed. Interpretation of toxicology r...

Toxicological determinations are crucial to coroners' or medical examiners' judgments that drugs are significantly involved in a death. However, differences in laboratory procedures, thoroughness of screening, and limits of detection may result in artifactual differences in the toxicological results and the subsequent interpretations of them. To test this possibility, we conducted a toxicology ...

This MiniReview describes the present guidelines for drug testing in forensic toxicology, workplace testing and doping control of athletes. Such guidelines are established to secure the chain of custody, from sample collection through analysis with screening, confirmation methods and interpretation, to the final report of results. Specifications for good laboratory practice, facility maintenanc...

In aviation accident investigations, specimens from fatal aircraft victims are analyzed for drugs. The presence of drugs suggests possible associated medical conditions for which they might have been taken. As drugs are mostly present in therapeutic to subtherapeutic levels in aviation forensic toxicology cases, determination of parent drugs and their metabolites in multispecimens is of signifi...

Ricin is one of the most fascinating poisons due to its high toxicity: as little as 500 microg can kill an adult. It gained fame by its use in the so-called 'umbrella murder' to kill the Bulgarian dissident Georgi Markov in 1978. Ricin also became known as a potential bio-terror agent to which people could be exposed through the air, food, or water. The origin, biochemistry, toxicity, and analy...