OBJECTIVE Methanol poisoning by ingestion is well represented in current emergency medicine literature. Much less described, however, is poisoning via intentional inhalation of methanol-containing products such as carburetor cleaner. This study intends to explore the exposure routes and treatment patterns of methanol cases reported to Texas Poison Centers. METHODS All cases of methanol exposu...

Using isolated Leydig cells prepared from adult rat testes, the effects of ethanol on testicular steroido genesis were examined in vitro. Ethanol over a dosage range of 25 to 1000 mg 3⁄4 markedly inhibited gona dotropin-stimulated testosterone production in a dose-dependent fashion. As little as 25 mg 3⁄4 (ca. 6 mM) ethanol was effective in reducing testosterone synthesis by 50%. By using 0.5 m...

We are the first to report allosterism during styrene oxidation by recombinant CYP2E1 and human liver microsomes. At low styrene concentrations, oxidation is inefficient because of weak binding to CYP2E1 (K(s) = 830 μM). A second styrene molecule then binds CYP2E1 with higher affinity (K(ss) = 110 μM) and significantly improves oxidation to achieve a k(cat) of 6.3 nmol · min(-1) · nmol CYP2E1(-...