Many myths are still present today in assisted reproductive techniques and particularly in infertility management. Most of them exist because we do not want to really look at the facts for various reasons. In this lecture we will review 7 of these myths: 1. HP-HMG improves pregnancy rates, 2. HMG prevents progesterone rise in follicular phase, 3. Clinical importance of progesterone rise in foll...

We tested the physiological reliability of plasma renin activity (PRA) and plasma concentrations of arginine vasopressin (P[AVP]), aldosterone (P[ALD]), and atrial natriuretic peptide (P[ANP]) in the early follicular phase and midluteal phases over the course of two menstrual cycles (n = 9 women, ages 25 +/- 1 yr). The reliability (Cronbach's alpha >/=0.80) of these hormones within a given phas...

Numerous studies have used human chorionic gonadotrophin (HCG) administration to study the response of the primate ovary to gonadotrophin stimulation. These studies are generally performed in the luteal phase with very few studies of the follicular phase. We have studied the effect of both HCG and gonadotrophin releasing hormone (GnRH) agonist administered at the early follicular phase in norma...

BACKGROUND Neuroticism, which is a personality trait characterized by the tendency to experience negative affect, is associated with premenstrual negative emotion changes. The present ERP study intended to investigate how neuroticism and the menstrual cycle influence the evaluation of emotion as a function of the tested levels of ovarian hormones. METHOD Forty-two healthy females with regular...

OBJECTIVE To investigate whether allopregnanolone, a neuroactive steroid involved in modulating behavioural and neuroendocrine functions, shows episodic secretion in eumenorrheic women, during the follicular and luteal phases of the menstrual cycle, and in women with stress-induced amenorrhea. PATIENTS Six eumenorrheic women and 14 women with hypothalamic amenorrhea were enrolled for the pres...

Objectives: This study aimed to assess how menstrual cycle phase and extended length influence the incidence of injuries in international footballers. Methods: Over a 4-year period, from England footballers at training camps or matches were recorded, alongside self-reported information on characteristics point injury. Injuries eumenorrheic players categorized into early follicular, late luteal ...

The objective of the present study was to evaluate changes in equine follicular fluid insulin-like growth factor binding protein (IGFBP) proteolytic activity as well as steroid, IGF, and IGFBP concentrations during follicular development in the mare. Mares (n = 14) were classified as either in the follicular phase (n = 8) or luteal phase (n = 6). Follicles (n = 92) were categorized as small (6 ...

Khan LH, Rosenfeld CR, Liu X, Magness RR. Regulation of the cGMP-cPKG pathway and large-conductance Ca -activated K channels in uterine arteries during the ovine ovarian cycle. Am J Physiol Endocrinol Metab 298: E222–E228, 2010. First published November 17, 2009; doi:10.1152/ajpendo.00375.2009.—The follicular phase of the ovine ovarian cycle demonstrates parallel increases in ovarian estrogens ...

PURPOSE Additional targeted therapeutics are needed for the treatment of lymphoma. Abexinostat is an oral pan-histone deacetylase inhibitor (HDACi) displaying potent activity in preclinical models. We conducted a multicenter phase I/II study (N = 55) with single-agent abexinostat in relapsed/refractory lymphoma. EXPERIMENTAL DESIGN In phase I, 25 heavily pretreated patients with any lymphoma ...

This study investigated the fluctuations of autonomic nervous activities during the menstrual cycle. Twenty college females were tested for cardiovascular reactivity to mental challenge during both follicular and luteal phases across two menstrual cycles. Power spectral analysis of heart rate variability (HRV) was used to examine the autonomic nervous activities. At baseline, although heart rat...