There is an unmet need for new antifungal or fungicide treatments, as resistance to existing treatments grows. Combination treatments help to combat resistance. Here we develop a novel, effective target for combination antifungal therapy. Different aminoglycoside antibiotics combined with different sulphate-transport inhibitors produced strong, synergistic growth-inhibition of several fungi. Co...

We have constructed a poker classification system which makes informed betting decisions based upon three defining features extracted while playing poker: hand value, risk, and aggressiveness. The system is implemented as a poker player agent, and as such, the goals of the classifier are not only to correctly determine whether each hand should be folded, called, or raised, but to win as many ch...

in this study we investigate voice productions of normal speakers and patients with varying vocal fold adduction deficiencies using a noninvasive method to measure spatial vibrations of the larynx. the current version accv4 of our acceleration sensor device was used. The study’s primary goal is to find out whether lesions of vocal folds lead to additional spatial vibration modes compared to a n...

To efficiently eliminate the noise generated by triaxial accelerometer when collecting pigs’ behavioural data, this paper adopted SNR and MSE as indexes to evaluate de-noising effect of acceleration signal under various combinations wavelet basis, decomposition layer, threshold rule function. Based on optimal parameter combinations, de-noised data were divided into a training dataset test condu...

Abstract Stochastic fluctuations at the transcriptional level contribute to isogenic cell-to-cell heterogeneity in mammalian cell populations. However, we still have no clear understanding of repercussions this heterogeneity, given lack tools independently control mean expression and variability a gene. Here, engineer synthetic circuit modulate transgenes endogenous human genes. The circuit, Tu...

The meaning of such verb-noun combinations as take care, undertake work, pay attention can be generalized as DO what is designated by the noun. Likewise, the meaning of make a decision, provide support, write a letter can be generalized as MAKE what is designated by the noun. These generalizations represent the meaning of certain groups of verb-noun combinations. We use supervised machine learn...

Biological responses often obey Weber's law, according to which the magnitude of the response depends only on the fold change in the external input. In this study, we demonstrate that a system involving a simple autocatalytic reaction shows such a response when a chemical is slowly synthesized by the reaction from a faster influx process. We also show that an autocatalytic reaction process occu...

The well-known third list homomorphism theorem states that if a function h is both an instance of foldr and foldl , it is a list homomorphism. Plenty of previous works devoted to constructing list homomorphisms, however, overlook the fact that proving h is both a foldr and a foldl is often the hardest part which, once done, already provides a useful hint about what the resulting list homomorphi...

The CCAAT box is one of the most common cis-elements present in eukaryotic promoters and is bound by the transcription factor NUCLEAR FACTOR Y (NF-Y). NF-Y is composed of three subunits, NF-YA, NF-YB, and NF-YC. Unlike animals and fungi, plants have significantly expanded the number of genes encoding NF-Y subunits. We provide a comprehensive classification of NF-Y genes, with a separation of cl...