the growth hormone gene could be an attractive candidate gene for milk production in goats. single-strand conformation polymorphism was used to identify polymorphism at the goat growth hormone (ggh) gene. for this purpose, genotyping of 90 talli goat breeds was performed. nine conformational patterns were observed in exon 4 of the ggh gene, with frequencies of 27.7% for the homozygous pattern (...

patients and methods manganese superoxide dismutase polymorphism was genotyped using polymerase chain reaction-restriction fragment length polymorphism (pcr-rflp) in 103 patients with mlds and 103 healthy control subjects. conclusions according to the fact that mn-sod gene polymorphisms have been considered as a major risk factor in some malignancies, this single center study did not find any a...

introduction: the coagulation factor 13 has a fundamental role in homeostasis, protective effects on thrombosis, and some other associated diseases. due to increasing the chronic coagulability of major thalassemic patients, this study was conducted with aim determining the prevalence of val34leufxiii polymorphism in the thalassemic patients. materials and methods: the present case-control study...

Introduction: The TP53 and CHEK2 genes have been described as breast cancer susceptibility some of their polymorphisms associated with an increased risk in certain populations.Aim: objective this study was to investigate the p.R72P PIN3 Ins16bp (TP53) I157T (CHEK2) mutation developping cancer. Methods: This case-control had enrolled 144 participants including 65 cases (breast patients) 79 contr...

background: leishmaniasis is a tropical disease that is endemic in some areas of iran, including east azerbaijan . ifn-γ is one of the cytokines that triggers cell-mediated immunity, thus initiating elimination of the infection. this case-control study was performed to investigate the association between the polymorphism of the ifn-γ gene at the +874a/t locus and visceral leishmaniasis (vl). me...

hla-g is a non-classical hla class ib molecule with limited protein variability generated by  alternative  splicing.  hla-g   displays  immunotolerant   properties  and  hence  plays important roles in the maintenance of a successful pregnancy and maternal tolerance of the semiallogenic fetus. polymorphism of the hla-g gene may potentially affect the biological properties of the protein, and a ...

background: potential association of leptin (lep) gene polymorphisms has been suggested in the processes leading to breast cancer initiation and progression. we investigated whether genetic variations in the lep -2548g/a gene are associated with risk of breast cancer. methods: this case-control study consisted of 100 breast cancer cases and 100 control subjects without breast cancer that matche...

in the present research, molecular detection of bovine leukocyte adhesion deficiency (blad) and complex vertebral malformation (cvm)in a population of iranian holstein cows has been carried outusing milk somatic cells by polymerase chain reaction-restriction fragment length polymorphism(pcr-rflp). the blad and cvm are monogenic and autosomal recessive heredity lethal syndrome in holstein-friesi...

background: leishmaniasis is important vector-borne parasitic disease worldwide, caused by the genus leishmania . the objective of the current study was to identify genetic polymorphism in l. major , one of the species causing cutaneous leishmaniasis (cl), isolated from southeastern iran, using permissively primed intergenic polymorphic-polymerase chain reaction (ppip-pcr) method. methods: over...

Introduction: Considering the effectiveness of polymorphisms in the occurrence of respiratory diseases, it seems that these genetic variations in viral and microbial receptors can be effective in the occurrence and progression of the disease. The present study aimed to  assess the relationship between the C-159T polymorphism in the CD14 gene promoter and the severity of the disease in  Covid-19...