BACKGROUND This study is a pre-registration trial of generic duloxetine that was approved by the China Food and Drug Administration (approval number: 2006L01603). AIMS Compare the treatment efficacy and safety of generic duloxetine to that of paroxetine in patients with major depressive disorders (MDD). METHODS This was a double-dummy, double-blind, multicenter, positive drug (paroxetine), ...

background and objectives: patients experience moderate to high level of anxiety before general surgery. there are differences in studies on the effect of listening quran to decrease anxiety in general surgery patients. the purpose of this study was to evaluate the effects of vaghe'a surah and its translation on the state - trait anxiety before general surgeries. methods: in this randomize...

OBJECTIVE To study the long-term effects of deep brain stimulation (DBS) of the bilateral subthalamic nucleus (STN) on depression in patients with Parkinson's disease (PD) and to discuss the mechanism. METHODS A STN-DBS group (n = 27) and anti-Parkinson's medication control group with paired designing were set up. The evaluation of the depression and motor function was performed a total of si...

BACKGROUND The aim of this study was to explore the relationships between depressive symptoms and health-related quality of life (HRQOL) measurements for inpatients with major depressive disorder (MDD) before and after 6-week fluoxetine treatment, and to elucidate the factors related to the HRQOL changes. METHODS A total of 131 inpatients with MDD were enrolled to receive 20 mg of fluoxetine ...

Previous studies have shown that pramipexole might have the potential to improve depressive symptoms in patients with Parkinson's disease. To provide more evidence, in five Japanese patients at Hoehn & Yahr stage 1-3 we evaluated the Unified Parkinson's Disease Rating Scale (UPDRS), Hamilton Depression Rating Scale (HAMD) and Montgomery Asberg Depression Rating Scale (MADRS) at our hospital. Af...

from a long time ago, religious scholars have been competing to best determine the very miracles of the holy quran. from among these scholars some have tended to its language, style and structure while some other have been absorbed by its scientific miracles. the present study is an attempt to analyze one of these miracles, i.e. miracle of sound. quran was first revealed unto muhammad (pbuh) in...

BACKGROUND Patients with irritable bowel syndrome (IBS) have significantly reduced quality of life (QOL). Although intestinal and extraintestinal symptoms, as well as comorbid psychological disorders, may reduce the QOL of IBS patients, the primary determinant of QOL in these patients remains unclear. This study aimed to identify the main factors affecting QOL in patients with IBS with diarrhea...

OBJECTIVE To assess the efficacy and tolerability of paroxetine 20mg daily, for the treatment of depression and depression associated with anxiety. METHOD An open, non-comparative study undertaken at three centers in three cities of Pakistan. A total of 112 in- or out-patients, presenting with a major depressive episode were included in the study. Depression was diagnosed according to DSM IV ...

This issue of the Journal is dedicated to Alvan R. Feinstein, the father of clinical epidemiology [1]. We like to join those who honor his memory and acknowledge his invaluable contribution to methodology in clinical research. The debate is still open and calls for reassessment of the field. As to psychometrics, the basis of measurement in psychiatry, Fava et al. [2] argue in this issue that it...

The objective of this study was to assess the efficacy and safety of electroacupuncture in 138 patients with earthquake-caused PTSD using Randomized Controlled Trials (RCTs). 138 cases enrolled were randomly assigned to an electro-acupuncture group and a paroxetine group. The electro-acupuncture group was treated by scalp electro-acupuncture on Baihui (GV 20), Sishencong (EX-HN 1), Shenting (GV...