In many cases bioavailability and toxicity of cationic metals in soils is determined by the free metal ion (FMI) activity in soil solution. Recently methods were developed that relate biological effects to FMI activity. The use, validation and further development of such approaches require determination of FMI activities in soil. FMI activity determination is, however, prone to methodological a...

This study investigated whether the riboflavin analogs, 7,8-dimethyl-10-formylmethyl isoalloxazine (FMI) and 7,8-dimethyl-10-(2'-hydroxyethyl) isoalloxazine (HEI), are effective antihypertensive agents in mineralocorticoid-induced or deoxycorticosterone acetate (DOCA)-salt hypertension. These studies are based on our previous observation tht aldosterone enhances the biosynthesis of renal flavin...

BACKGROUND A low or high body mass index (BMI) has been associated with increased mortality risk in older subjects without taking fat mass index (FMI) and fat-free mass index (FFMI) into account. This information is essential because FMI is modulated through different healthcare strategies than is FFMI. OBJECTIVE We aimed to determine the relation between body composition and mortality in old...

CONTEXT Polymorphism at the insulin gene (INS) variable number of tandem repeat (VNTR) shows variable associations with childhood body mass index (BMI) in different populations. OBJECTIVE The objective of this study was to observe INS VNTR associations with body composition and insulin secretion in children. DESIGN The study was designed as a prospective birth cohort study. PARTICIPANTS A...

Objective The current study investigated associations between mothers' and fathers' distress reported in early childhood (at ages 9 months 3 years) adiposity trajectories from 5 to 14 years. Methods Linear mixed-effects models were undertaken the Millennium Cohort Study. Self-reported maternal paternal was measured at BMI fat mass index (FMI) modeled years, adjusting for socioeconomic child cha...

Background. Asthma and obesity are common; however the impact of obesity upon asthma remains uncertain. Objectives. To assess relationships between obesity and fat mass with airway inflammation, lung function, and disease control in patients with refractory asthma. Methods. 151 refractory asthma patients were characterised for measures of airway inflammation, lung function, Juniper asthma contr...

The Functional Mock-up Interface (FMI) is an industry standard which enables co-simulation of complex heterogeneous systems using multiple simulation engines. In this paper, we show how to use FMI in order to co-simulate hybrid systems modeled in the model checkers SPACEEX and UPPAAL. We show how FMI components can be automatically generated from SPACEEX and UPPAAL models. We also validate the ...

Co-simulation refers to simulating a complex system using several coupled numerical models. Engineers define the rate of data exchange between the models by setting communication steps. FMI is a standardized interface which easily allows coupling and co-simulation of numerical models. The RCOSIM approach allows the parallelization on multi-core processors of co-simulations using the FMI standar...

The objective of Task T2.4 is to provide formal foundations for comodelling with the Functional Mockup Interface (FMI). In Year 2, we have created the first behavioural semantics for the FMI standard. We use the state-rich process algebra, Circus, to present our modelling approach, and indicate how models can be automatically generated from a description of the individual simulations and their ...