نتایج جستجو برای: fmd vaccine
تعداد نتایج: 111553 فیلتر نتایج به سال:
The historical background of foot and mouth disease (FMD) vaccine production is briefly described. Improvements achieved through the use of monolayer and suspension cultures are outlined. Elements that are crucial in the production of modern vaccines are discussed, such as inactivation of viral antigen, successive concentration and purification of the antigen and the final formulation of the va...
Foot and Mouth Disease (FMD) control is a national regional responsibility. FMD outbreaks were detected in three farms Port-Said Governorate 2020, although animals these vaccinated with the local polyvalent inactivated vaccine. Samples from tongue epithelium vesicular fluid collected farms, where FMDV isolation was performed on BHK-21 cell culture. Viral RNA extracted virus isolates, vaccine st...
We investigated to what extent maternally derived antibodies interfere with foot-and-mouth disease (FMD) vaccination in order to determine the factors that influence the correct vaccination for piglets. Groups of piglets with maternally derived antibodies were vaccinated at different time points following birth, and the antibody titers to FMD virus (FMDV) were measured using virus neutralizatio...
There are seven antigenically distinct serotypes of foot-and-mouth disease virus (FMDV), each of which has intratypic variants. In the present study, we have developed methods to efficiently generate promising vaccines against seven serotypes or subtypes. The capsid-encoding gene (P1) of the vaccine strain O1/Manisa/Turkey/69 was replaced with the amplified or synthetic genes from the O, A, Asi...
The present study reports kinetics of anti-P. multocida antibody (Ab) response at monthly intervals in Murrah buffaloes different age groups vaccinated against combined Foot-and-mouth disease+haemorrhagic septicaemia (FMD+HS) vaccine. A total 60 three having 20 animals each: calves, heifers and adults were used to monitor Ab using single dilution indirect ELISA. percentage adult protected found...
Introduction: Foot-and-mouth disease (FMD) serotype A is endemic in Afghanistan, Iran, Pakistan and Turkey, while sporadic outbreaks occur in the southern Middle Eastern countries. Periodically new genetic lineages appear to spread in a westward direction from Iran into Turkey, the best known event being the spread of the A22 strain throughout the Middle East from 1964 onwards. The precise orig...
Caron L., Brum M.C.S., Moraes M.P., Golde W.T., Arns C.W. & Grubman M.J. 2005. [Granulocyte-macrophage colony-stimulating factor does not increase the potency or efficacy of a foot-and-mouth disease virus subunit vaccine.] Pesquisa Veterinária Brasileira 25(3):150-158. USDA, ARS, PIADC-FMD Research Unit, PO.Box 848, Greenport, NY 11944 0848, USA. E-mail: [email protected] Foot-and-mou...
Control and prevention of foot and mouth disease (FMD) by vaccination remains unsatisfactory in endemic countries. Indeed, consistent and new FMD epidemics in previously disease-free countries have precipitated the need for a worldwide control strategy. Outbreaks in vaccinated animals require that a new and safe vaccine be developed against foot and mouth virus (FMDV). FMDV can be eradicated wo...
The foot-and-mouth disease virus (FMDV) afflicts livestock in more than 80 countries, limiting food production and global trade. Production of foot-and-mouth disease (FMD) vaccines requires cytosolic expression of the FMDV 3C protease to cleave the P1 polyprotein into mature capsid proteins, but the FMDV 3C protease is toxic to host cells. To identify less-toxic isoforms of the FMDV 3C protease...
Chimeric foot-and-mouth disease viruses (FMDV) of which the antigenic properties can be readily manipulated is a potentially powerful approach in the control of foot-and-mouth disease (FMD) in sub-Saharan Africa. FMD vaccine application is complicated by the extensive variability of the South African Territories (SAT) type viruses, which exist as distinct genetic and antigenic variants in diffe...
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