Fluoro-substituted flavones and 2-styrylchromones, related to natural and synthetic flavonoids previously described, were prepared, characterized and tested for anti-rhinovirus activity. Structural elucidation of the new compounds was performed by IR, NMR spectra and X-ray crystal structure analysis for 6-fluoro-3-hydroxy-2-styrylchromone. The antiviral potency was evaluated by a plaque reducti...

Hydrogen-fluorine exchange in the NaBH4-NaBF4 system is investigated using a range of experimental methods combined with DFT calculations and a possible mechanism for the reactions is proposed. Fluorine substitution is observed using in situ synchrotron radiation powder X-ray diffraction (SR-PXD) as a new Rock salt type compound with idealized composition NaBF2H2 in the temperature range T = 20...

Exogenous tryptophan is metabolized by Pseudomonas aureofaciens to yield pyrrolnitrin [3-chloro-4-(2'-nitro-3'-chlorophenyl)-pyrrole], an antifungal agent. The ability of this culture to metabolize tryptophan analogues in a similar manner was investigated by addition of the appropriate compound to the fermentation. Tryptophan precursors and metabolites or nonphenyl-substituted tryptophans had l...

A series of paddlewheel diruthenium(ii, ii) complexes with various chlorine-substituted benzoate ligands (Cl-series) was synthesized as tetrahydrofuran (THF) adducts [Ru2(ClxPhCO2)4(THF)2]; where ClxPhCO2(-) = o-chlorobenzoate, ; m-chlorobenzoate, ; p-chlorobenzoate, ; 2,3-dichlorobenzoate, ; 2,4-dichlorobenzoate, ; 2,5-dichlorobenzoate, ; 2,6-dichlorobenzoate, ; 3,4-dichlorobenzoate, ; 3,5-dic...

The synthesis and the solution/solid-state fluorescence properties of pyrimidine-based monoboron complexes differing in terms of the substituents [either two fluorine atoms (BF2 complex) or two phenyl groups (BPh2 complex)] on the boron atom are reported herein. Unrestricted C-Ar intramolecular rotation in the non-, trifluoromethyl-, and cyano-substituted derivatives resulted in negligible fluo...

The main motive of the study is to analyze and compare crystallographic changes using X-Ray diffraction method for zinc substituted hydroxyapatite. Materials Methods: Different types hydroxyapatite are used. Calcium nitrate tetrahydrate, chloride hexahydrate, diammonium hydrogen phosphate ammonium hydroxide solutions added they mixed with solution. ultrasonic was used carry precipitation method...

Effect of SiO2 addition on the microstructures of calcium-deficient hydroxyapatite prepared by the heat-treatments was examined. Obtained hydroxyapatites substituted with Si ion were characterized by XRD, FT-IR and XAFS measurements. XANES results of Si K-edge and P K-edge in these modified hydroxyapatites indicated the shift of peaks of P K-edge with the SiO2 contents, although no change of Si...

A series of new arylfluoroquinolones has been prepared. These derivatives are characterized by having fluorine atoms at the 6- and 8-positions, substituted amino groups at the 7-position, and substituted phenyl groups at the 1-position. The in vitro antibacterial potency is greatest when the 1-substituent is 2,4-difluorophenyl and the 7-substituent is a 3-amino-1-pyrrolidinyl group. 1-(4-Fluoro...

The design and synthesis of two series of 8-(substituted styrol-formamido)phenyl-xanthine derivatives are described. Their in vitro monoamine oxidase B (MAO-B) inhibition were tested and the effect of substituents on the N-7, phenyl and the substituted positions are discussed. It was observed that compound 9b displayed significant MAO-B inhibition activity and selectivity, fluorine substitution...