STATEMENT OF THE PROBLEM Severely injured trauma victims are at high risk of development of the multiple organ dysfunction syndrome (MODS) or death. To maximize chances for survival, treatment priorities must focus on resuscitation from shock (defined as inadequate tissue oxygenation to meet tissue O2 requirements), including appropriate fluid resuscitation and rapid hemostasis. Inadequate tiss...

BACKGROUND & AIMS Early fluid resuscitation is recommended to reduce morbidity and mortality among patients with acute pancreatitis, although the impact of this intervention has not been quantified. We investigated the association between early fluid resuscitation and outcome of patients admitted to the hospital with acute pancreatitis. METHODS Nontransfer patients admitted to our center with...

BACKGROUND Optimising the fluid resuscitation of patients with severe malaria is a simple and potentially cost-effective intervention. Current WHO guidelines recommend central venous pressure (CVP) guided, crystalloid based, resuscitation in adults. METHODS Prospectively collected haemodynamic data from intervention trials in Vietnamese adults with severe malaria were analysed retrospectively...

1 o i C m m n a i w t i e d s DESPITE IMPROVEMENTS in resuscitation and supportive care, progressive organ dysfunction occurs in a large proportion of patients with acute, life-threatening illnesses and those undergoing major surgery.1-5 Recent data suggest that early aggressive resuscitation of critically ill patients may limit and/or reverse tissue hypoxia and progression to organ failure and...

OBJECTIVE The objective of the present study was to explore the resuscitative effect of small-volume resuscitation on uncontrolled hemorrhagic shock in emergency. METHODS In this study, the resuscitative effects in 200 trauma patients with uncontrolled hemorrhagic shock in emergency were studied. Half of these patients were infused with hypertonic/hyperoncotic fluid (small-volume resuscitatio...

Sepsis is a systemic inflammatory response to severe infection causing significant morbidity and mortality that costs the health care system $20.3 billion annually within the United States. It is well established that fluid resuscitation is a central component of sepsis management; however, to date there is no consensus as to the ideal composition of fluid used for resuscitation. In this review...

In 2010 the SAFE-TRIPS investigators reported on resuscitation fluid administration in 391 intensive care units (ICUs) in 25 countries.(1) The study found that more than one third of patients in the ICUs received resuscitation fluids on the study day and that the choice of fluid administered was determined by local practice and habit rather than by any identifiable patient characteristic. Given...