The complement system is a complex cascade involving proteolytic cleavage of serum glycoproteins often activated by cell receptors. This cascade ultimately results in induction of the inflammatory response, phagocyte chemotaxis and opsonization, and cell lysis. Complement factors C3a, C5a, and C4 can induce vasodilatation, increased capillary permeability, and expression of leukocyte adhesion m...

and Explanation Depressed fibrinogen levels are found in a) acquired hypofibrinogenemia or afibrinogenemia Acquired fibrinogen deficient conditions occur especially as a result of intravascular proteolysis of fibrinogen by thrombin (consumption coagulopathy e.g. in obstetrics, following surgical intervention), snake venom or plasmin (primary hyperfibrinolysis following therapy with streptokinas...

INTENDED USE MBL Bion REAGENTS FOR IFA (Indirect Fluorescent Antibody) TESTS may be used in assays for the qualitative and/or semi-quantitative determination of specific IgG or IgM antibodies in human serum. The MBL Bion REAGENTS FOR IFA TESTS are intended for use as an aid in diagnosis of certain autoimmune diseases or for primary or active infection and/or as a determination of immunological ...