Floating drug delivery system is one of the novel drug delivery system. Floating drug delivery system have a bulk density less than gastric fluids and thus it remains buoyant in the stomach without affecting gastric emptying rate for a prolonged period of time. Verapamil HCL is calcium channel blocker drug with short elimination half-life 2.8-7.4 hours Floating microspheres of Verapamil HCL wer...

Oral drug delivery route is the most preferable route of drug delivery. It is due to various advantages of this route like ease of administration, patient compliance and flexibility in the formulations. Oral dosage form has really progressed from immediate release to site-specific delivery. The recent scientific and patented literature concluded that an increased interest in novel dosage forms ...

Novel drug delivery system overcomes the physiological problems of gastric retention by decreasing fluctuations in blood drug concentration with consequent reduction in undesirable toxicity and poor efficiency. Incorporation of drug in controlled release gastroretentive dosage forms which can remain in the gastric region for several hours would significantly prolong the gastric residence time o...

Drugs that have narrow absorption window in the gastro-intestinal tract (GIT) will have poor absorption. For these drugs, gastro-retentive drug delivery systems offer the advantages in prolonging the gastric emptying time. Floating and sustained release tablets are developed by using a combination of hydrophilic polymer (Hydroxypropyl methylcellulose) and effervescent substance (Sodium bicarbon...

Floating matrix tablets or stomach specific drug delivery systems are designed to prolong the gastric residence time after oral administration, at a particular site and controlling the release of drug, especially useful for achieving controlled plasma level as well as improving bioavailability. Due to low gastric retention time, the bioavailability of acyclovir is low as the large portion of dr...

Floating tablets of Marichyadi Vati were developed with an aim to prolong its gastric residence time and increase the bioavailability of drug. Rapid gastrointestinal transit could result in incomplete drug release from the drug delivery system above the absorption zone leading to diminished efficacy of the administered dose. The tablets were prepared by wet granulation technique, using HPMC E50...

Introduction A modified release drug delivery system with prolonged residence time in the stomach is of particular interest for drugs: (a) that are locally acting in the stomach, (b) that have an absorption window in the stomach or in the upper part of small intestine, (c) that are unstable in the intestinal or colonic environments, or (d) have low solubility at high pH values. Systems that pro...