A Novel floating controlled release drug delivery system of famotidine was formulated in an effort to increase the gastric retention time of the dosage form and to control drug release. The present work investigates the approach using two different polymers HPMC K100 M and natural polymer Chitosan . A floating drug delivery system (FDDS) was developed using gas-forming agents, like sodium bicar...

intravitreal injection is the most common approach for drug delivery to the posterior segment in humans. however, following the injection, drugs are rapidly eliminated from the vitreous, with half-lives up to a few days. depending on the rate of clearance from the vitreous, large boluses and frequent administrations may be required to ensure therapeutic levels over an extended period of time. m...

Floating drug delivery system provides the advantage of sustained release of drugs over a prolonged period of time thereby maximising the oral absorption of drugs with narrow absorption window, thus, it overcomes the drawback of conventional oral drug delivery system. In situ gelling system is a novel approach in this regard. The aim of the present work was to develop an oral sustained stomach ...

The purpose of writing this review on Hollow microspheres is to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric retention. Hollow microsphere promises to be a potential approach for gastric retention. The recent developments of FDDS including approaches to design single-unit and multiple-unit floating systems, mechanism of floating mi...

All the pharmaceutical products formulated for systemic delivery via the oral route of administration, irrespective of the mode of delivery (immediate, sustained or controlled release) and the design of dosage form (solid dispersion or liquid), must be developed within the intrinsic characteristics of GI physiology. The recent scientific and patented literature concluded that an increased inter...

Using ion-exchange resins, a multiple-unit type of oral floating dosage system has been prepared to prolong gastric emptying time of dosage form. The system is composed of beads of drug-resin complex, which are loaded with bicarbonate ions and coated with a hydrophobic polymer. The system is so designed that when the beads reach the stomach, chloride ions are exchanged with bicarbonate and drug...