In vivo quantitative measurement of biodistribution plays a critical role in the drug/probe development and diagnosis/treatment process monitoring. In this work, we report a probe, named AIE-SRS-Mito, for imaging mitochondria in live cells via fluorescence (FL) and stimulated Raman scattering (SRS) imaging. The probe features an aggregation-induced emission (AIE) characteristic and possesses an...

Due to the large surface area-to-volume ratio and high quality crystal structure, single nanowire (NW)-based UV sensors exhibit very high on/off ratios between photoresponse current and dark current. Practical applications require a large-scale and low-cost integration, compatibility to fl exible electronics, as well as reasonably high photoresponse current that can be detected without high-pre...

T appropriate management of adults with filum lipoma (FL) with normal neurological status remains unclear.1,2 Factors such as younger age at presentation, low-lying conus medullaris (CM), thick FL, and the proximity of fat to the CM has not been consistent in the literature in predicting the development of neurological deficits.1-3 The objective of the present study was to evaluate radiological...

BACKGROUND Connexin 43 (Cx43) is a major determinant of conduction in the ventricular working myocardium of mammals. We investigated the effect of decreased Cx43 expression on conduction velocity and arrhythmogenesis using adult mice with inducible deletion of Cx43. METHODS AND RESULTS Cx43Cre-ER(T)/+ mice, in which 1 coding region of the Cx43 gene was replaced by Cre-ER(T), were mated to Cx4...

Within the tropical and subtropical oceans, tuna forage opportunistically on a wide variety of prey. However, little is known about the trophic ecology of the smallest size classes which play an important role in stock assessments and fisheries management. The foraging behavior of yellowfin tuna, Thunnus albacares (23.5–154.0 cm FL), collected from nearshore Fish Aggregating Devices (FADs) arou...

One hundred and ninety two records were taken weekly for twenty four (24) weeks from West African Dwarf (WD), the Yankasa (YN) X crossbred (XB) sheep. The traits evaluated milk yield (MK), linear body measurements (LB) such as height at withers, (HT), length (BL), heart girth (HG), shoulder width (SW), Tail (TA), Neck (NL), circumference (NC), Face (FA), Hind leg (HL), Foreleg (FL), Ear (EA), H...

This paper describes the fabrication of large (up to 45 cm(2)) arrays of microwells, with volumes as small as ∼3 fL/well and densities as high as 10(7) wells/cm(2). These arrays of microwells are formed by casting an elastomer, poly(dimethylsiloxane) (PDMS), against "masters" prepared by photolithography; arrays of microwells in other polymers can be formed by using a master consisting of posts...