Rats with radiofrequency lesions of the fimbria/fornix, or neurotoxic lesions of the mammillary bodies or the anterior thalamic nuclei were tested on their ability to perform a delayed non-matching-to-position task that had been learnt before surgery. In this task rats had to respond to a sample lever in an operant chamber and, after a variable delay (during which they were required to respond ...

The capsular polysaccharide and type 1 fimbriae are two of the major surface-located virulence properties associated with the pathogenesis of Klebsiella pneumoniae. The capsule is an elaborate polysaccharide matrix that encases the entire cell surface and provides resistance against many host defense mechanisms. In contrast, type 1 fimbriae are thin adhesive thread-like surface organelles that ...

anterior commissure, cc = corpus callosum, cp = caudate putamen, cpd = cerebral peduncle, em = external medullary lamina of thalamus, int = internal capsule, ml = medial lemniscus; fi = fimbria, fr = fasciculus retroflexus, fx = fornix, hf = hippocample fissure; mtt = mammilothalmic tract; sm = stria medularis, vhc = ventral hippocampal commissure. Magnetization Transfer Mapping of Myelinated F...

The tubal fimbria is a common site of origin for early (tubal intraepithelial carcinoma or TIC) serous carcinomas in women with familial BRCA1 or 2 mutations (BRCA+). Somatic p53 tumour suppressor gene mutations in these tumours suggest a pathogenesis involving DNA damage, p53 mutation, and progressive loss of cell cycle control. We recently identified foci of strong p53 immunostaining-termed '...