BACKGROUND There is a clinical need for new technologies that would enable rapid disease diagnosis based on diagnostic molecular signatures. Ambient ionization mass spectrometry has revolutionized the means by which molecular information can be obtained from tissue samples in real time and with minimal sample pretreatment. New developments in ambient ionization techniques applied to clinical re...

We investigate the discrete orbital angular momentum (OAM) of photoelectrons freed in strongfield ionization. use these `twisted' electrons to provide an alternative interpretation on existing experimental work vortex interferences caused by strong field ionization mediated two counterrotating circularly polarized pulses separated a delay. Using approximation, we derive interference condition f...