The tricyclic core of lycoposerramine S has been synthesised in 10 steps from a symmetrical cyclohexadiene precursor by way of a desymmetrising free-radical cyclisation and iodocyclisation.

This paper explores why occupational therapists use arts and crafts as therapeutic modalities. Beginning with the turn-of-the-century origins of occupational therapy, the paper traces the similarities and differences in the ideas and beliefs of the founders of occupational therapy and the proponents of the arts-and-crafts movement.

A dimeric proline derived diamidobinaphthyl dilithium salt represents the first example of a chiral main group metal based catalyst for asymmetric hydroamination/cyclisation reactions of aminoalkenes.

The FeCl3·6H2O-catalyzed three-component aza-Friedel-Crafts reaction of aromatic/heteroaromatic compounds, aromatic aldehydes and tert-butyl carbamate was reported. The subsequent Friedel-Crafts-type alkylation of the resulting tert-butyl diarylmethyl carbamate with heteroaromatic compounds under "open-flask" at room temperature was also performed. The two-step reaction was especially useful fo...

An enantioselective Friedel-Crafts alkylation with alpha,beta-unsaturated 2-acyl imidazoles and electron-rich aromatic nucleophiles catalyzed by bis(oxazolinyl)pyridine-scandium(III) triflate complexes has been accomplished. These alpha,beta-unsaturated 2-acyl imidazoles are effective electrophiles for the Friedel-Crafts reaction. The resulting adduct 2-acyl imidazole is easily converted to ami...

Understanding the factors that influence N → S acyl transfer in native peptide sequences, and discovery of new reagents that facilitate it, will be key to expanding its scope and applicability. Here, through a study of short model peptides in thioester formation and cyclisation reactions, we demonstrate that a wider variety of Xaa-Cys motifs than originally envisaged are capable of undergoing e...

A novel intramolecular Prins type cyclisation of cyclopropylvinylic aldehydes promoted by TiCl(4) under mild reaction conditions to form cis-cyclic products in high yields has been accomplished.

Xanthates derived from unprotected 2-hydroxyacetophenones undergo smooth intermolecular addition to unactivated alkenes and subsequent cyclisation to give hydroxytetralones in good yield.

Based on the perspective of academic application and cultural dissemination, this study intends to explore the aesthetic value of Taiwan modern crafts. Through an approach of style analysis, this study examines the works selected from Taiwan Crafts Competition Award and Modern Crafts Yii Project. Both qualitative and quantitative methods are employed to explore the artistic essence and cultural...