BACKGROUND Early-life exposures to hormonally active compounds and other factors may affect later response to estrogen or progesterone and hence may influence development of uterine leiomyomata (fibroids). OBJECTIVES We evaluated associations of in utero and early-life exposures, including soy formula, with self-report of physician-diagnosed fibroids by 35 years of age. METHODS Our study in...

The aetiology of uterine fibroids remains unknown, despite causing significant gynaecological morbidity. Fibroids have a reduced microvascular density when compared with adjacent myometrial tissue. The aim of this study was to identify genes with differential expression between fibroid and adjacent normal myometrium, particularly genes with a role in angiogenesis. Total RNA was extracted from f...

Background: Uterine fibroid is the most common benign tumor in reproductive age group, arising from single smooth muscle cell of uterus. Steroid hormones, estrogen, and progesterone are considered to be important links pathophysiology uterine fibroid; meanwhile estrogens influence several aspects lipid metabolism; so it's possible theorize a relationship between size dyslipidemia. Aim study was...

The ideal medical therapy for fibroids is, arguably, a tablet that is taken by mouth, once a day or, even better, once a week, with minimal, if any, side-effects, that induces fibroid regression and thus a resolution of symptoms rapidly, but without affecting fertility. Such a magic bullet does not yet exist, and there are no indications that one is on the horizon. Driven by the observation tha...

OBJECTIVE To estimate the prevalence of anemia, pelvic pain and heavy vaginal bleeding among symptomatic women with and without submucosal fibroids who presented for uterine fibroid embolization (UFE), and to determine if uterine weight was related to patient reports of heavy bleeding and pelvic pain. STUDY DESIGN A case series study was performed that reviewed the ambulatory medical records ...

This is a case report of a 29-year-old lady who presented with excessive vaginal discharge and sessile cervical fibroid arising from the vaginal portion of the cervix. She was not suitable for uterine artery embolization as she has never previously been pregnant before. She was encouraged to get pregnant and to avoid surgical excision which can lead to hysterectomy. Shortly after, she became pr...

BACKGROUND A number of studies have found associations between heavy metals and uterine fibroids, but the results are inconsistent. Here, we conducted this research to demonstrate the relationships between blood heavy metal concentrations and uterine fibroid volume as well as the rate of uterine fibroid presence. METHODS In a cross-sectional study, we collected data from 308 premenopausal wom...

BACKGROUND & OBJECTIVE Uterine fibroid embolization is an effective treatment alternative for uterine fibroids. However, amenorrhea after uterine fibroid embolization occurs in some patients. This study was to investigate the causes of amenorrhea after uterine fibroid embolization. METHODS Bilateral transcatheter uterine artery embolization was performed in 487 patients with uterine fibroids....

BACKGROUND Early-life soy phytoestrogen exposure has been shown in Eker rats to increase uterine fibroid incidence in adulthood. Two large epidemiologic cohorts have provided some support for increased fibroid risk with infant soy formula feeding in women, but both cohorts relied on self-report of clinically diagnosed fibroids. OBJECTIVE We evaluated the relationship between infant soy formul...

Inflammatory fibroid polyps are uncommon but well documented solitary polypoid lesions occurring in gastrointestinal tract; most commonly in stomach followed by ileum and rarely in colon, duodenum and oesophagus. Polyps in ileum most commonly present with acute intestinal obstruction as a result of intussusception. We describe one case of inflammatory fibroid polyps of the small intestine causi...