T hrombosis is a dynamic process in which procoagulant activity, which promotes platelet activation and fibrin deposition, is balanced by physiologic anticoagulant and fibrinolytic activity. Historically, the treatment of thrombosis has been based on the use of agents that either inhibit procoagulant activity (i.e., anticoagulants) or induce fibrinolytic activity (i.e., plasminogen activators)....

The distribution of fibrinolytic activity in the tissues of the male genital tract was studied by a histological technique. Preparations made from testis, epididymis, vas deferens, seminal vesicle, prostate, bulbo-urethral gland, and urethra showed that most activity was related to the blood vessels. However, inconsistent fibrinolytic activity related to epithelium was found in all parts of the...

Recombinant variants of tissue plasminogen activator (t-PA) containing either substitutions or deletions of amino acids within the fibronectin finger-like domain (residues 6-50) were found to exhibit widely varying in vivo clearance profiles in rats and fibrinolytic activity in 125I-fibrin clot lysis assays. Clearance was not significantly affected by changes in the densely charged region of am...

The urine and serum fibrinolytic activity were measured in dogs following whole body radiation ranging from 450 to 800 r generated by 1,000 kv. and 250 kv. machines. The fibrinolytic activity of the urine showed a precipitate rise 4 to 5 days before death in all dogs with pulmonary hemorrhage as the main cause of death. The fibrinolytic activity of the serum showed a similar rise, which was mos...

Three ;normal' groups of people-young, middle-aged, and old-have been investigated with regard to the fibrin content and fibrinolytic activity of the blood. The fourth group consisted of middle-aged people who had previously sustained a cerebral vascular accident matched statistically for age with the middle-aged normals. It was concluded that fibrin increases with age but there is an interacti...

Crotalus durissus cumanensis snake venoms from different Venezuelan regions, showed biochemical and hemostatic variations. Fibrino(geno)lytic, hemorrhagic and procoagulant activities and gel-filtration chromatography and SDS-PAGE profiles were analyzed. Differences were observed in fibrinolytic activity: kallikrein-like amidolytic activity was highest in venoms of Santa Teresa, and Margarita. L...

Background: In spite of the high incidence of gingivitis and periodontal disease in the hemophiliac population, few are known about the influence of oral health condition as risk factor for bleeding after dental extraction in this patient population. The aim of this report is to use a group of patients under oral anticoagulation as a model of acquired bleeding disorder to show the importance of...

]n the thronibogenic theory of the pathogenesis of arteriosclerotic lesions, parietal fibrin deposits in the arteries play a primary role. In an effort to elucidate the heinostatic system in the arterial wall, the thromboplastic activity and the fibrinolytic activity (estimated as plasminogcn activator) in the layers of the human aorta have been estimated. The simultaneous presence of high thro...

ORTHOTOPIC liver transplantation is frequently associated with hemostatic disorders and a bleeding diathesis.I.2 Accelerated fibrinolysis has been recognized as an important component of the hemostatic defectY The origin of this fibrinolytic activity, however, is still unclear. We investigated the role of tissue-type plasminogen activator (tPA). a potent activator of the fibrinolytic system, in...