ORTHOTOPIC liver transplantation is frequently associated with hemostatic disorders and a bleeding diathesis.I.2 Accelerated fibrinolysis has been recognized as an important component of the hemostatic defectY The origin of this fibrinolytic activity, however, is still unclear. We investigated the role of tissue-type plasminogen activator (tPA). a potent activator of the fibrinolytic system, in...

Thrombus lysis is the consequence of a restricted number of reactions localized on the surface of fibrin and cell membranes. A functional defect or an insufficient fibrinolytic response may lead to thrombosis with severe or fatal clinical consequences. Despite this clinical need, and real progress in the knowledge of the different components of this system (plasminogen activators, inhibitors an...

Fibrinolytic enzymes have nowadays found important place in the medical field. Only few studies had reported the fibrinolytic enzyme production from actinomycetes. So the microbial fibrinolytic enzymes, especially those from actinomycetes, have the potential to be developed as drugs to prevent cardiovascular diseases. Actinomycetes were producing strong enzymes with no side effects, non pathoge...

Fibrinolytic enzymes are proteases that capable of degrading the fibrin mesh present in blood clots and can be obtained through fungal extracts. Thus, objective this paper was to seek out compare all information regarding production biochemical characterization fibrinolytic mushroom species published papers last ten years. The research carried eight national international electronic databases u...

Platelets stimulate tissue factor, the initiator of the extrinsic coagulation pathway, and increase fibrinolytic inhibition in fibroblasts grown in vitro. Cellular tissue factor increases an average of 2.8-fold over the control levels after a 6-hr incubation with platelets, and no activity is present in the media. Fibrinolytic inhibition is stimulated in both the fibroblasts and their media in ...

Cardiovascular diseases, such as heart attack and stroke, are the leading causes of death in North America. According to data provided by the World Health Organization in 2000, heart diseases are responsible for 29% of the total mortality rate in the world. Since cardiovascular diseases have a major impact on an individual s quality of life, a tremendous amount of research has been done in the ...

BACKGROUND Limitations in physicians' knowledge regarding fibrinolytic therapy for acute ischemic stroke may contribute to low rate of fibrinolytic therapy in China. Here physicians' knowledge was surveyed on intravenous fibrinolytic therapy for acute ischemic stroke. METHODS Neurologists (n = 175) from 27 major general hospitals in Shanxi province, P. R. China, were invited to complete quest...