Abstract Objective Cardiac dysfunction is a major cause of death in patients with beta thalassemia. In these patients, repeated blood transfusion, ineffective erythropoiesis and increased gastrointestinal iron absorption lead to iron overload in the body and this induced heart failure. Left ventricular ejection fraction was measured in major beta thalassemia (β-Th) patients to detect the rela...

conclusions in the setting of acute left ventricular function depression in hocm, a comprehensive differential diagnosis should be established. treatment should be based on hemodynamic changes. after recovery, the prognosis is related to hocm. case presentation we present a unique case where tks occurred in a middle-aged male patient with hypertrophic obstructive cardiomyopathy (hocm) without a...

BACKGROUND Placental insufficiency may lead to fetal cardiovascular compromise. We sought to determine whether ultrasonographic parameters of fetal cardiovascular function correlate with umbilical arterial levels of biochemical markers of myocardial dysfunction and damage in placental insufficiency. METHODS AND RESULTS In 48 fetuses with placental insufficiency, umbilical artery blood was obt...

Timely generation and normal maturation of ependymal cells along the aqueduct are critical for preventing physical blockage between the third and fourth ventricles and the development of fetal non-communicating hydrocephalus. Our study identifies Yap, the downstream effector of the evolutionarily conserved Hippo pathway, as a central regulator for generating developmentally controlled ependymal...

OBJECTIVE The upper limit of the fetal atrial width in normal fetuses is debated. This was a prospective cohort evaluation of the lateral ventricular width with special regard to the upper limit of its size. METHODS Measurements of fetal atrial ventricular size were obtained by abdominal ultrasonography in 427 male and female fetuses between 20 and 40 weeks' gestation of normal singleton preg...

BackgroundNifedipine is a widely used drug in pregnancies complicated by maternal hypertensive disorders that can be associated with placental insufficiency and fetal hypoxemia. The evidence regarding myocardial responses to nifedipine hypoxemia limited.ObjectiveWe hypothesized would not impair sheep cardiac function under hypoxemic environment. In particular, we investigated the effects of on ...

conclusions the vibratory innocent murmur is associated with the presence of left ventricular false tendon and higher left ventricular outflow tract velocity. the presence of the left ventricular false tendon was somewhat associated with decreased early diastolic myocardial velocity. normal left ventricular systolic and diastolic function can be used as a reassurance in cases with the vibratory...

The fetal and the maternal cardiovascular compartment undergo dramatic functional changes during pregnancy. In this thesis we examined the heart of fetuses with twin-to-twin transfusion syndrome (TTTS) and congenital diaphragmatic hernia (CDH) using two new ultrasound parameters of ventricular function : the myocardial performance index and speckle tracking derived myocardial strain. Fetal card...

OBJECTIVE We analyzed the association between renal and cardiovascular parameters in fetuses with isolated severe urinary tract malformations. METHODS 39 fetuses at a mean gestational age of 23.6 weeks with nephropathies or urinary tract malformations and markedly impaired or absent renal function were prospectively examined. Fetal echocardiography was performed, and thicknesses of the interv...