WILLIAMS, ID. M., G. K. LEE, AND G. E CARTWRIGIIT. Fb-roxidasc nctivity of rat ccruloplasmin. Am. J. Physiol. 227(5) : 1094-1097. 1974.-The ferroxidase activity of rat ceruloplasmin was studied under various assay conditions. The ferroxidase activity was optimal at pH 6.0-6.2 in acetate buffer in the absence of ascorbate, and under these conditions the activity was about 1/3rd that of human cer...

Hephaestin is a large membrane-anchored multicopper ferroxidase involved in mammalian iron metabolism. Newly absorbed dietary iron is exported across the enterocyte basolateral membrane by the ferrous iron transporter ferroportin, but hephaestin increases the efficiency of this process by oxidizing the transported iron to its ferric form and promoting its release from ferroportin. Deletion or m...

A marked increase in the serum copper and caeruloplasmin levels in 25 female subjects taking oral contraceptives is noted. The correlation between the copper and caeruloplasmin concentrations, together with the finding of normal urine copper levels in 10 of the subjects, suggests that the increased serum copper is due to increased caeruloplasmin synthesis.

To the Editor: Ambade et al1 conducted an observational study to evaluate the potential serum biomarkers in subjects with COPD. The authors assessed superoxide dismutase-3, glutathione peroxidase, catalase, ceruloplasmin ferroxidase activity, C-reactive protein, and surfactant protein D in the serum of subjects with COPD and reported that ceruloplasmin ferroxidase activity and glutathione perox...

The iron redox cycle in ferritins is not completely understood. Bacterioferritins are distinct from other that they contain haem groups. It acknowledged the two motifs bacterioferritins, di-nuclear ferroxidase centre and B group, play key roles opposing processes, sequestration mobilisation, respectively, processes independent. Herein, we show Escherichia coli bacterioferritin, there an electro...