Feline coronavirus (FCoV) is an enveloped single-stranded RNA virus, of the family Coronaviridae and the order Nidovirales. FCoV is an important pathogen of wild and domestic cats and can cause a mild or apparently symptomless enteric infection, especially in kittens. FCoV is also associated with a lethal, systemic disease known as feline infectious peritonitis (FIP). Although the precise cause...

Coronaviruses infecteddifferent species of animals, such as feline, canine, swine and bovine. Inveterinary medicine, a significant fatal coronavirus disease in Felidae is FelineInfectious Peritonitis (FIP). The Internet provided many websites about smallanimals that present educational content for prevention, pets welfare,etc. Upper than 90% internet users chooses Google search engine. In2008, ...

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Measurement of feline coronavirus (FCoV) antibody titres is utilised mainly for diagnosing feline infectious peritonitis (FIP) and for quarantine purposes. However, occasional samples show a falsely low or negative FCoV antibody test. We tested the hypothesis that such results are due to virus in the sample binding antibody and rendering it unavailable to antigen in the test. Thirteen effusions...

We have cloned, sequenced and expressed the spike (S) gene of canine coronavirus (CCV; strain K378). Its deduced amino acid sequence has revealed features in common with other coronavirus S proteins: a stretch of hydrophobic amino acids at the amino terminus (the putative signal sequence), another hydrophobic region at the carboxy terminus (the membrane anchor), heptad repeats preceding the anc...

One of the most poorly understood and enigmatic feline viruses is the feline coronavirus (FCoV), a large enveloped positive-stranded RNA virus. Two primary forms of FCoV are recognized, a relatively harmless enteric form (FECV) and the feline infectious peritonitis (FIP) disease causing form (FIPV). FIP is invariably a lethal, systemic immune-mediated disease. The most popular etiological hypot...

In feline coronavirus (FCoV) pathogenesis, the ability to infect macrophages is an essential virulence factor. Whereas the low-virulence feline enteric coronavirus (FECV) isolates primarily replicate in the epithelial cells of the enteric tract, highly virulent feline infectious peritonitis virus (FIPV) isolates have acquired the ability to replicate efficiently in macrophages, which allows rap...