BACKGROUND Recent investigations of febrile neutropenia in pediatric cancer patients have identified subsets of low-risk patients who can be managed with less antibiotic therapy than previously recommended standards. METHODS AND MATERIALS PubMed and Medline were searched for prospective trials and reviews of febrile neutropenia in children. Magnitude and duration of fever and neutropenia, com...

INTRODUCTION Rising rates of antibiotic resistance prompted a review of antibiotic use policies hospitalwide. The Department of Haematology established a new set of consensus guidelines in 2002 for antibiotic use in febrile neutropenia. The aim of our study was to audit adherence to the guidelines established for febrile neutropenia in patients treated for haematologic malignancies. MATERIALS...

Brucellosis is an important zoonosis predominantly afflicting animal and dairy product handlers. Its occurrence as a hospital acquired infection especially in febrile neutropenia has been reported only rarely. We present a case of acute myeloid leukemia that developed febrile neutropenia during the course of induction chemotherapy when blood culture grew brucella. He responded to appropriate an...

Febrile neutropenia is the major dose-limiting toxicity of anticancer chemotherapy in small cell lung cancer (SCLC). Nadir and duration of neutropenia have been correlated to the risk of developing sepsis [1], increasing healthcare costs and deteriorating quality of life. Despite empirical broad-spectrum antibiotic therapy at the onset of fever and dose reduction of chemotherapy during subseque...

Intensive chemotherapy/radiotherapy in cancer, especially with hematologic malignancies, causes cellular injury and suppression of inflammatory responses, which increase the risks neutropenia febrile episodes. Absolute neutrophil count < 1 ? 109/L is considered neutropenia, absolute 0.5 or that expected to decrease next 48 hours severe while 0.1 109 referred as profound neutropenia. Febrile ...

Febrile neutropenia is common in children with leukemia. Mucous membrane and skin are most common portals of entry for microorganisms in these patients. The aim of the present study was to find the prevalence of mucocutaneous findings infebrile neutropenic leukemic children. The authors prospectively examined children with fever with neutropenia in acute leukemia, aged 1-15 years, who were admi...

Neutropenic fever is an oncologic emergency that requires prompt assessment and treatment with antibiotics. Although the term "prompt" is not defined in numbers of minutes in the biomedical literature, the literature does indicate that the sooner antibiotics are initiated, the greater the likelihood of a positive clinical outcome. At Dartmouth-Hitchcock Medical Center in Lebanon, NH, the oncolo...

DOI: 10.5581/1516-8484.20130002 The management of neutropenia is a challenge in the clinical practice. It is known since the 1960s that risk of infection is associated with the intensity and duration of neutropenia(1). Neutropenic patients with an infection usually present incomplete signs and symptoms considering the severity of the condition. Thus, rubor, erythema and pustules may not be seen...

The present study was aimed to evaluate the incidences of chemotherapy-induced neutropenia and febrile neutropenia in the patients with solid tumors in India. The patients with carcinomas of breast, lung, ovary, colon, head and neck, and liver were divided in two groups. Group 1 was for the patients who experienced grade 0-2 neutropenia and Group 2 was for the patients with grade 3-4 neutropeni...