FEAST (Finite Element Analysis & Solutions Tools) is a Finite Element based solver toolkit for the simulation of PDE problems on parallel HPC systems which implements the concept of ‘hardware-oriented numerics’, a holistic approach aiming at optimal performance for modern numerics. In this paper, we describe this concept and the modular design which enables applications built on top of FEAST to...

Lysosomal storage diseases are metabolic disorders characterized by the accumulation of acidic vacuoles, and are usually the consequence of the deficiency of an enzyme responsible for the metabolism of vesicular lipids, proteins or carbohydrates. In contrast, mucolipidosis type IV (MLIV), results from the absence of a vesicular Ca ( 2+) release channel called mucolipin 1/transient receptor pot...

FEAST (Finite Element Analysis & Solutions Tools) is a Finite Element based solver toolkit for the simulation of PDE problems on parallel HPC systems which implements the concept of ‘hardware-oriented numerics’, a holistic approach aiming at optimal performance for modern numerics. In this paper, we describe this concept and the modular design which enables applications built on top of FEAST to...