Familial essential thrombocythemia features the acquisition of somatic mutations and an evolution similar to the sporadic form of the disease. Here we report two patients-father and daughter-with essential thrombocythemia who displayed a heterogeneous pattern of somatic mutations. The JAK2 V617F mutation was found in the daughter, while the father harbored the MPL W515L mutation. This case repo...

Retrospective data were entered anonymously by 1,521 adult women using computer-assisted self-interview. Nineteen were classified as victims of father-daughter incest, and 241 were classified as victims of sexual abuse by an adult other than their father before reaching 18 years of age. The remaining 1,261 served as controls. Incest victims were more likely than controls to endorse feeling dama...

Background Familial amyloid polyneuropathy (FAP ATTRV30M) is an autosomal dominant systemic amyloidosis, due to a point mutation in the transthyretin (TTR) gene (chr18q12.1). The most frequent one, V30M is associated with several clusters. Among Portuguese families, FAP shows a wide variation in in age-at-onset (AO) [19-82 yrs] and this variability is also apparent between generations. Also, si...

Background The family under investigation consists of parents and two daughters, one being the proband. The mother and the proband have elongated facial features. The father and second daughter appear normal. The older daughter presented for elective tonsillectomy aged 8 years. She had severe masseter spasm after suxamethonium. The rest of the procedure was carried out under total intravenous a...

The issue of incest has been extensively debated for a long time. However, the argument concerning father-daughter (FDI) began in 1980s. Many scholars disscuss factors that contribute to as well consequences abuse. This paper applied Systematic Literature Review (SLR) explore issues and challenges faced by survivors incest, comprising 12 social science articles across 12-year period (2010 July ...

Table 1 reports coe¢ cient estimates from systems of seemingly unrelated regressions, where each dependent variable is a dummy for working at baseline in a one-digit industry and the right hand side is a dummy for the father or mother being in that industry and a dummy for the parent working, in addition to race, age, and education …xed e¤ects1. So as to not multiple count individuals, I use th...