Fat and carbohydrate are the principal substrates that fuel aerobic ATP synthesis in skeletal muscle. Most endogenous fat is stored as triacylglycerol in subcutaneous and deep visceral adipose tissue. Smaller quantities of triacylglycerol are deposited as lipid droplets inside skeletal muscle fibers. The potential role of intramyocellular triacylglycerol (IMTG) as a substrate source during exer...

Energy expenditure and fat oxidation are both profoundly increased in exercise. In absolute terms, fat oxidation is greatest during exercise of moderate intensity (60-65 % maximum 0 2 uptake, vo2,,) when subjects following a mixed diet may oxidize between 0.3 and 0.7g fat/min, rFpresenting up to 60% of energy expended (Saltin & Astrand, 1993). Because the capacity of muscle fibres to synthesize...

Fat and carbohydrate are the primary fuel sources for mitochondrial ATP production in human skeletal muscle during endurance exercise. However, fat exhibits a relatively low maximal rate of oxidation in vivo, which begins to decline at around 65% of maximal oxygen consumption (VO2max) when muscle glycogen becomes the major fuel. It is thought that if the rate of fat oxidation during endurance e...

Purpose We investigated the effects of endurance training on the expression of long-chain fatty acid transport proteins in the skeletal muscle and whole-body fat oxidation during endurance exercise. Methods Seven-week-old male ICR mice (n = 12) were divided into 2 groups, namely, Sed (sedentary; non-trained) and Tr (endurance-trained) groups. The Tr group was adapted to treadmill training at ...

The study investigated the accumulative effect of concentric-biased and eccentric-biased exercise on cardiorespiratory, metabolic and neuromuscular responses to low-intensity exercise performed hours later. Fourteen young men cycled at low-intensity (~60 rpm at 50% maximal oxygen uptake) for 10 min before, and 12 h after: concentric-biased, single-leg cycling exercise (CON) (performed ~19:30 h)...

BACKGROUND The purpose of this study was to determine the appropriate exercise intensity associated with maximum fat oxidation, improvement of body composition, and metabolic status in Korean women with type 2 diabetes mellitus (T2DM). METHODS The study included a T2DM group (12 women) and a control group (12 women). The groups were matched in age and body mass index. The subjects performed a...

Compared with the limited capacity of the human body to store carbohydrate (CHO), endogenous fat depots are large and represent a vast source of fuel for exercise. However, fatty acid (FA) oxidation is limited, especially during intense exercise, and CHO remains the major fuel for oxidative metabolism. In the search for strategies to improve athletic performance, recent interest has focused on ...

This study examined the differences in fat and carbohydrate oxidation during running and cycling at the same relative exercise intensities, with intensity determined in a number of ways. Specifically, exercise intensity was expressed as a percentage of maximum workload (WL(max)), maximum oxygen uptake (%VO(2max)), and maximum heart rate (%HR(max)) and as rating of perceived exertion (RPE). Ten ...