نتایج جستجو برای: farahzads cda model

تعداد نتایج: 2106251  

Journal: :Genome research 2007
Tomer Shlomi Markus Herrgard Vasiliy Portnoy Efrat Naim Bernhard Ø Palsson Roded Sharan Eytan Ruppin

The task of deriving a functional annotation for genes is complex as their involvement in various processes depends on multiple factors such as environmental conditions and genetic backup mechanisms. This study employs a large-scale model of the metabolism of Saccharomyces cerevisiae to investigate the function of yeast genes and derive a condition-dependent annotation (CDA) for their involveme...

Journal: :Studies in health technology and informatics 2004
Marcel Lucas Müller Thomas Frankewitsch Thomas Ganslandt Thomas Bürkle Hans-Ulrich Prokosch

The Clinical Document Architecture (CDA) has proved to be a valuable and powerful standard for a structured exchange of clinical documents between heterogeneous software systems like a Hospital Information System and a Physician Office System. In this paper we want to show how the CDA can additionally be used in order to enhance the Hospital Information System's functionality: each patient rela...

2007
Christopher Hart

Critical Discourse Analysis (CDA) explores the role of discourse structures in constituting social inequality. Metaphorical structure, however, has received relatively little attention in explicit CDA. The paper aims to redress this by developing a coherent theoretical framework for CDA and metaphor. This framework adopts conceptual blending theory over conceptual metaphor theory, where the lat...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2001
S Cardoen E Van Den Neste C Smal J F Rosier A Delacauw A Ferrant G Van den Berghe F Bontemps

The effects of 2-chloro-2'-deoxyadenosine (CdA, cladribine), an adenosine deaminase-resistant analogue toxic for both proliferating and resting lymphoid cells, were investigated in the human leukemia cell line EHEB, which was derived from a patient with B-cell chronic lymphocytic leukemia. These cells were found to be less sensitive to CdA than B-cell chronic lymphocytic leukemia lymphocytes (a...

2012
Quteba Ebrahem Reda Mahfouz Kwok Peng Ng Yogen Saunthararajah

We document for the first time that sanctuary in an organ which expresses high levels of the enzyme cytidine deaminase (CDA) is a mechanism of cancer cell resistance to cytidine analogues. This mechanism could explain why historically, cytidine analogues have not been successful chemotherapeutics against hepatotropic cancers, despite efficacy in vitro. Importantly, this mechanism of resistance ...

2012
Xuan Wang Cui-Min Jiang Hai-Ying Wan Jun-Lu Wu Wen-Qiang Quan Robert Bals Kai-Yin Wu Dong Li

CDA-2 (cell differentiation agent 2), a urinary preparation, has potent anti- proliferative and pro-apoptotic properties in cancer cells. However, the mechanisms of tumor inhibitory action of CDA-2 are far from clear, and especially there was no report on lung cancer. Here we demonstrate that CDA-2 and its main component phenylacetylglutamine (PG) reduce the metastatic lung tumor growth, and in...

1995
Dattatraya Kulkarni Michael Stumm

In this paper we present a new loop transformation technique called Computation Decomposition and Alignment (CDA). Computation Decomposition rst decomposes the iteration space into ner computation spaces. Computation Alignment subsequently, linearly transforms each computation space independently. CDA is a general framework in that linear transformations and its recent extensions are just speci...

Journal: :Blood 1993
Z Reiter S Tomson O N Ozes M W Taylor

Hairy cell leukemia (HCL) is a lymphoproliferative disorder of B lymphocytes. Interferons (IFNs), especially of the alpha (alpha) subtype, have shown a significant antitumor effect in HCL patients. However, the therapeutic effect of IFN-alpha is still rather limited. The purine analogue 2-chlorodeoxy-adenosine (2-CdA) was reported recently to be an effective agent in the treatment of HCL. In th...

2009
Zul Premji Rich E. Umeh Seth Owusu-Agyei Fabian Esamai Emmanuel U. Ezedinachi Stephen Oguche Steffen Borrmann Akintunde Sowunmi Stephan Duparc Paula L. Kirby Allan Pamba Lynda Kellam Robert Guiguemdé Brian Greenwood Stephen A. Ward Peter A. Winstanley

BACKGROUND Chlorproguanil-dapsone-artesunate (CDA) was developed as an affordable, simple, fixed-dose artemisinin-based combination therapy for use in Africa. This trial was a randomized parallel-group, double-blind, double-dummy study to compare CDA and artemether-lumefantrine (AL) efficacy in uncomplicated Plasmodium falciparum malaria and further define the CDA safety profile, particularly i...

2007
Christopher Hart

Critical Discourse Analysis (CDA) explores the role of discourse structures in constituting social inequality. Metaphorical structure, however, has received relatively little attention in explicit CDA. The paper aims to redress this by developing a coherent theoretical framework for CDA and metaphor. This framework adopts conceptual blending theory over conceptual metaphor theory, where the lat...

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