normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 colorectal cancer is classified in to three forms: sporadic (70-75%), familial (20-25%) and hereditary (5-10%). hereditary colorectal cancer syndromes classified into two different subtypes: polyposis and non polyposis. familial adenomatous polyposis (fap; omim #175100) is the most common polyposis syndrome, account for <1...

This century has seen a leap forward in both treatment and understanding of the molecular and pathogenetic mechanisms underlying aortic dissection. The advantages of endovascular stenting are becoming obvious, and results from the Investigation of Stent Grafts in Patients With Type B Aortic Dissection (INSTEAD) trial are pending.1 Molecular and pathogenetic advances include genetic defects mapp...

We describe a case of schwannomatosis presenting as radicular pain and numbness in multiple radicular nerve distributions. There were multiple peripheral nerve tumors detected by magnetic resonance imaging (MRI) at the left vestibular nerve, cauda equina, right radial nerve, thoracic paraspinal nerve, and brachial plexi. Several resected tumors have features of schwannomas, including hypercellu...

A full term boy was admitted with respiratory distress in the fourth week of his life due to spontaneous chylothorax in his right hemithorax. Spontaneous chylothorax occurred previously in a first cousin of the neonate establishing that way the final diagnosis of familial idiopathic congenital pneumothorax. Failure of the conservative treatment consisting of chest tube drainage, discontinuation...

Aortopathies pose a significant healthcare burden due to excess early mortality, increasing incidence, and underdiagnosis. Understanding the underlying genetic causes, early diagnosis, timely surveillance, prophylactic repair, and family screening are keys to addressing these diseases. Next-generation sequencing continues to expand our understanding of the genetic causes of heritable aortopathi...

Primary hyperparathyroidism (PHPT) is a common endocrine disorder that mainly affects middle-aged women. Patients are usually asymptomatic. The disease might be ascribable to hyperplasia, carcinoma, and single or multiple adenomas. PHPT may be sporadic or familial, the latter comprising multiple endocrine neoplasia type 1 or 2A, familial benign hypocalciuria hypercalcemia, and hyperparathyroidi...

intrathoracic gossypiboma, a retained surgical sponge in the thoracic cavity, is a rare but serious complication of thoracic surgeries. a 70-year-old man presented with an eight-month history of cough. he had undergone coronary artery bypass surgery eight years ago. the posteroanterior chest x-ray revealed a well-marginated homogeneous opacity at the left hemithorax with striped appearance in t...

financial and economic relationships are undeniable realities and impressive factors in familial relations, and there are reciprocal interactions between these two. the existence of this relationship has caused the familial relations to be realized as effective in the penal destiny of aggressions against properties in the penal jurisprudence and statutes. in islamic jurisprudence, familial immu...