BACKGROUND Previous studies of families with fronto-temporal dementia (FTD) support an autosomal dominant inheritance pattern, but most studies have described genetic transmission in individual families specifically selected for the presence of multiple affected individuals. OBJECTIVE To investigate the familial presentation and inheritance of FTD and related disorders among a large group of ...

Monoclonal antibodies raised by synthetic peptide immunisation were used to determine the distribution of the protein product of the c-myc gene by immunocytochemical staining of archival wax embedded material from patients with familial adenomatous polyposis. Polyps from 18 cases of familial adenomatous polyposis, 10 of whom had developed malignant change, and 30 normal control colonic biopsy s...

As the authors describe, the initial evidence that pulmonary fibrosis may have a genetic basis emerged from case reports and case series that reported multiple cases of idiopathic interstitial pneumonias (IIPs) clustering in families [2–6]. The epidemiology indicates that within families containing two or more cases of IIP (familial interstitial pneumonia) the development of familial interstiti...

The spatio-temporal analysis of residential fires could allow decision makers to plan effective resource allocations in fire management according to fire clustering levels in space and time. In this study, we provide guidelines for the use of various methods in detecting the differences in clustering patterns of fire and non-fire (i.e., background residential) locations and how these patterns c...