Background In young patients, multiple osteomas in the jaw and sebaceous cysts are signs which usually precede the diagnosis of Gardner’s syndrome. It is the association of multiple colonic polyps (familial adenomatosis polyposis coli) and extracolonic findings. By the fourth decade of life the colonic polyps undergo malignant transformation. Case reports The oral manifestations are described i...

Colorectal cancer (CRC) is the second leading cause of death in the United States, claiming 56,730 lives in 2004. 146,940 new cases are diagnosed each year, (age standardized incidence 53/100,000) making it 3rd in American cancer incidence, with a lifetime risk estimate of -61/6. Risk factors for CRC include but are not limited to inherited CRC syndromes, inflammatory bowel disease, diabetes me...

BACKGROUND Fundic gland polyps (FGPs) of the stomach were originally described in association with familial polyposis syndromes. It is now known that the majority of these polyps occur in the sporadic setting and are incidentally seen in up to 1.9% of routine upper gastrointestinal endoscopes. The aim of this study was to look at the clinico-pathological features of the FGPs and to analyse thei...

familial adenomatous polyposis (fap) is a hereditary autosomal dominant cancer syndrome, results from germ line mutation or deletion of the adenomatous polyposis coli (apc) gene on chromosome 5q21. patients with fap suffer from multiple polyps mainly at the colorectal region as well as other parts of the gastrointestinal tract, which has propensity to transform into carcinoma. fap has also been...

objectives: familial adenomatous polyposis (fap) is an autosomal dominant predisposition to colon cancer. this hereditary genetic disease is characterized by more than 100 adenomatous polyps in colon and rectum. additional features may include desmoids tumors, polyps in the upper gastrointestinal tract, osteomas and congenital hypertrophy of the retinal pigment epithelium (chrpe). a mutation in...

The tumor suppressor gene Smad4 (DPC4) at chromosome 18q21.1 belongs to the Smad family, which mediates the TGFbeta signaling pathway suppressing epithelial cell growth. This review summarizes the mutational events of the Smad4 gene in human cancer. The Smad4 gene is genetically responsible for familial juvenile polyposis, an autosomal dominant disease characterized by predisposition to gastroi...