OBJECTIVE To analyze participant factors that affect the diagnostic performance of screening mammography. MATERIALS AND METHODS We enrolled 128756 cases from 10 hospitals between 2005 and 2010. We analyzed recall rate, cancer detection rate (CDR) per 1000 examinations, positive predictive value (PPV), sensitivity, specificity, false positive rate (FPR), and interval cancer rate (ICR) per 1000...

The receiver operating characteristic (ROC) curve, which is defined as a plot of test sensitivity as they coordinate versus its 1-specificity or false positive rate (FPR) as the x coordinate, is an effective method of evaluating the performance of diagnostic tests. The purpose of this article is to provide a nonmathematical introduction to ROC analysis. Important concepts involved in the correc...

Data leakage causes significant losses and privacy breaches worldwide. In this paper we present a white-box data leakage detection system to spot anomalies in database transactions. We argue that our approach represents a major leap forward w.r.t. previous work because: i) it significantly decreases the False Positive Rate (FPR) while keeping the Detection Rate (DR) high; on our experimental da...

Identifying genes indispensable for an organism's life and their characteristics is one of the central questions in current biological research, and hence it would be helpful to develop computational approaches towards the prediction of essential genes. The performance of a predictor is usually measured by the area under the receiver operating characteristic curve (AUC). We propose a novel meth...

OBJECTIVE To determine the effect of a low-lying placenta on the concentration of quantitative fetal fibronectin (qfFN) in the cervicovaginal fluid (CVF), and predictive accuracy for spontaneous preterm birth in asymptomatic high-risk women (18 + 0-24 + 0 weeks gestation). METHODS Median concentrations of qfFN were compared in women who had a low-lying placenta, covering the cervical os (n = ...

OBJECTIVE The objective of the study was to evaluate risk assessment for gestational hypertension based on the profile of circulating placental specific C19MC microRNAs in early pregnancy. STUDY DESIGN The prospective longitudinal cohort study of women enrolled at first trimester screening at 10 to 13 weeks was carried out (n = 267). Relative quantification of placental specific C19MC microRN...

INTRODUCTION End-of-life decisions after stroke should be guided by accurate estimates of the patient's prognosis. We assessed the accuracy of physicians' estimates regarding mortality, functional outcome, and quality of life in patients with severe stroke. METHODS Treating physicians predicted mortality, functional outcome (modified Rankin scale (mRS)), and quality of life (visual analogue s...

OBJECTIVES To derive a model and examine the performance of first-trimester screening for trisomy 18 by maternal age, fetal nuchal translucency (NT) thickness, and maternal serum free beta-human chorionic gonadotropin (beta-hCG) and pregnancy-associated plasma protein-A (PAPP-A). METHODS Prospective combined screening for trisomy 21 was performed at 11 + 0 to 13 + 6 weeks in 56 893 singleton ...

BACKGROUND A beneficial consequence of screening for trisomy 21 is the early diagnosis of trisomies 18 and 13. Our objective was to examine the performance of first-trimester screening for trisomies 21, 18 and 13 by maternal age, fetal nuchal translucency (NT) thickness, fetal heart rate (FHR) and maternal serum-free beta-hCG and pregnancy-associated plasma protein-A (PAPP-A). METHODS Prospec...

This document demonstrates how to use the GeneSelectMMD package to detect significant genes and to estimate false discovery rate (FDR), false non-discovery rate (FNDR), false positive rate (FPR), and false negative rate (FNR), for a real microarray data set based on the method proposed by Qiu et al. (2008). It also illustrates how to visualize the fit of the model proposed in Qiu et al. (2008) ...