Background: Falciparum malaria is a severe health burden worldwide. Antigen presenting cells are reported to be affected by erythrocytic stage of the parasite. Malarial hemozoin (HZ), a metabolite of malaria parasite, has adjuvant properties and may play a role in the induction of immune response against the parasite. Objective: To determine the immunological impact of hemozoin on the capacity ...

Background& Objectives: Inspite of intensive worldwide efforts to reduce its transmission, malaria remains the most serious and widespread protozoal infection of humans. It is a protozoan disease transmitted by the bite of infected female anopheles mosquito. Malaria has long featured prominently in the grey area between parasitology and hematology. This study has been...

background: the number of malaria cases is declining worldwide; however, it remains as a serious health problem. diagnosing unusual cases is the most im­portant issue to manage the problem. this study designed to describe the number of falciparum and vivax malaria infected patients referred to malaria reference labora­tory in tehran university of medical science from 2000 to 2012. methods: a re...

background: parasite lactate dehydrogenase ( p ldh) is extensively employed as malaria rapid diagnostic tests (rdts). moreover, it is a well-known drug target candidate. however, the genetic diversity of this gene might influence perfor­mance of rdt kits and its drug target candidacy. this study aimed to determine polymorphism of p ldh gene from iranian isolates of p. vivax and p. falciparum. m...

Abstract Severe malaria (SM) is a major public health problem in malaria-endemic countries. Sequestration of Plasmodium falciparum–infected erythrocytes vital organs and the associated inflammation leads to organ dysfunction. MicroRNAs (miRNAs), which are rapidly released from damaged tissues into host fluids, constitute promising biomarker for prognosis SM. We applied next-generation sequencin...

BACKGROUND Very limited information is available on epidemiology of falciparum malaria in Nepal. Such information is very important for malaria control programmes. It is believed that malaria in Eastern region is imported from border districts of India and local transmission follows whereas it is indigenous in Central region. Therefore, the characteristics and risk factors of malaria are believ...

Although the preventive action of dapsone against P. falciparum malaria was known for many years, there was no report about the incidence of P. falciparum malaria in leprosy patients treated with dapsone, especially from areas of Southeast Asia where both leprosy and malaria are endemic. Therefore, two clinic-based malaria surveys were undertaken at a gap of 12 years, comprising 506 lepromatous...

Malaria imposes great socio-economic burden on humanity and one of the highest killer diseases affecting most tropical countries. More than 2 billion people (40% of the world's population) live in areas where malaria is endemic. It was estimated that over 250 million people worldwide contracted malaria in 2002 (Doderer et al., 2007). According to the UNICEF, in every minute, malaria kills a chi...