Florigen, a protein encoded by the FLOWERING LOCUS T (FT) in Arabidopsis and Heading date 3a (Hd3a) in rice, is the universal flowering hormone in plants. Florigen is transported from leaves to the shoot apical meristem and initiates floral evocation. In shoot apical cells, conserved cytoplasmic 14-3-3 proteins act as florigen receptors. A hexameric florigen activation complex (FAC) composed of...

t(14;18) translocation has been recognized as a genetic hallmark of follicular lymphoma (FL), but it is now known that additional genetic aberrations are required for the development of FL. With recent advances in the technology for DNA analysis, recurrent gene aberrations such as TNFRSF14, EPHA7, EZH2, CREBBP, EP300, MLL2 and MEF2B have been identified. A few t(14;18)-positive B cells can be d...

Brassinosteroids are essential hormones for plant growth and development. Genetic studies have identified key components of the BR signaling pathway, including the cell-surface receptor kinases that perceive BR, an intracellular kinase and a phosphatase, and nuclear transcription factors. Subsequent biochemical studies have revealed many details about signaling events from BR perception at the ...

1. Certain of the alpha-mercapto soaps and alpha-disulfo soaps are powerful germicides. 2. In the alpha-mercapto series, those soaps with 12 and 14 carbon atoms are most germicidal. In the disulfo series, the dicaprate, dilaurate, and dimyristate are most germicidal. The optimum number of carbon atoms varies with the test organism used. 3. These soaps, like others previously studied, show a mar...

What do the recently determined crystal structures of 14-3-3 proteins and of a complex between part of the protein kinase Raf and the Ras-related protein Rap tell us about how 14-3-3 and Ras regulate the function of Raf?

The synthesis and the biological and pharmacological evaluation of several 14-phenylpropoxy analogues of 14-methoxymetopon are described. Most of the new compounds were nonselective and exhibited binding affinities in the subnanomolar or low nanomolar range at opioid receptors mu, kappa, delta), with 14-phenylpropoxymetopon (PPOM; 7) displaying the highest affinity for all three opioid receptor...