Abstract Extramammary Paget disease (EMPD) is a rare epithelial malignancy predominantly affecting the anogenital skin. Primary EMPD carries risk of invasion and metastasis, as well in contiguous organs. No UK guidelines for management exist, resulting lack consensus staging screening associated cancers. We collected consecutive cases histologically diagnosed at regional centre (2017–2022). The...

BACKGROUND Clear cell papulosis is a rare condition that has been reported in 14 children, all but 1 of whom are of Asian descent. It was first described in 1987 and is thus named because of the presence of clear cells in the epidermis. OBSERVATION We describe the cases of 3 Hispanic children in the United States with clear cell papulosis. All 3 patients presented with multiple grouped, oval,...

Extramammary Paget disease (EPD) is a rare malign neoplasm that may affect the vulva and has manifestations common to benign diseases such as itching, pain and eczema. This leads to delay in diagnosis and consequent worse prognosis. The definitive diagnosis is obtained by biopsy of the vulva, which shows Paget cells. The treatment of choice is wide excision with margins, which leads to sequelae...

Introduction: We report an elderly gentleman with Extramammary Paget’s disease (EMPD) treated Mohs micrographic surgery (MMS) using Toluidine blue staining intraoperatively as to detect the cells. Case Presentation: An man presented erythematous plaque on left inguinal fold which showed in-situ EMPD histopathological examination. Investigations for secondary were negative and patient was MMS. D...

Cristina Anton, Arthur Vicentini da Costa Luiz, Filomena Marino Carvalho, Edmund Chada Baracat, Jesus Paula Carvalho I Obstetrics and Gynecology – Faculdade de Medicina da Universidade de São Paulo São Paulo/SP, Brazil. II Pathology – Faculdade de Medicina da Universidade de São Paulo, São Paulo/SP, Brazil. III Gynecology – Hospital das Clı́nicas da Faculdade de Medicina da Universidade de São P...

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Extramammary Paget disease (EMPD) involving the perianal region is rare and challenging to manage. Primary EMPD involves stand-alone noninvasive lesions within the epidermis, while secondary EMPD involves phenotypically similar lesions derived from separate underlying malignancies. Differentiating between primary and secondary EMPD is challenging when no underlying malignancies are detected dur...