نتایج جستجو برای: extrahepatic biliary atresia ehba

تعداد نتایج: 41630  

Journal: :Journal of clinical pathology 1992
J Mathew A R Cattan A G Hall J E Hines R Nelson E Eastham A D Burt

AIMS To investigate the distribution of alpha and pi class glutathione S-transferases (GST) in normal fetal, neonatal, and adult liver; and to examine changes in GST expression in neonatal liver disease. METHODS alpha and pi class GST were immunolocalised in sections of formalin fixed liver tissue obtained from human fetuses (n = 21), neonates (n = 8), young children (n = 9) and adults (n = 1...

2013
Jaishri Ramji Rakesh S Joshi Mitesh Bachani Dungarsingh Rathore

The syndromic form of biliary atresia accounts for 10-25% and is associated with a poor prognosis due to associated anomalies. We report a case of extrahepatic biliary atresia and polysplenia syndrome with jaundice since 19th day of life and who had undergone surgical correction of malrotation in the neonatal period. Inspite of successful Kasai's portoenterostomy at 52nd day of life, the child ...

Journal: :Archives of disease in childhood 1989
R H Houwen R P Zwierstra R S Severijnen J Bouquet G Madern A Vos N M Bax H S Heymans C M Bijleveld

We carried out a retrospective investigation of the 89 patients with extrahepatic biliary atresia born in The Netherlands during a 10 year period. Of these 89 patients 10 had a diagnostic laparotomy only. Eight patients had an anastomosis between the proximal bile duct and the intestine, and the remaining 71 had hepatic portoenterostomies. Bile drainage was re-established in 46 (65%). After suc...

Journal: :Annals of the Academy of Medicine, Singapore 1999
V Vijayan C E Tan

In the development of the human biliary system, the extrahepatic bile ducts (EHBD) develop from the embryonic hepatic diverticulum, while the intrahepatic bile ducts (IHBD) originate within the liver from the ductal plate. The ductal plate is a flat muralium of primitive biliary epithelium that develops in the mesenchyme along the branches of the portal vein, by a process which requires a delic...

Journal: :Archives of Disease in Childhood 1984

Journal: :The Journal of clinical investigation 2009
Pranavkumar Shivakumar Gregg E Sabla Peter Whitington Claire A Chougnet Jorge A Bezerra

Biliary atresia is a neonatal obstructive cholangiopathy that progresses to end-stage liver disease. Although the etiology is unknown, a neonatal adaptive immune signature has been mechanistically linked to obstruction of the extrahepatic bile ducts. Here, we investigated the role of the innate immune response in the pathogenesis of biliary atresia. Analysis of livers of infants at diagnosis re...

2015
James E. Squires Pranavkumar Shivakumar Reena Mourya Kazuhiko Bessho Stephanie Walters Jorge A. Bezerra Gianfranco Alpini

UNLABELLED Biliary atresia is a rapidly progressive obstructive cholangiopathy of infants. Mechanistic studies in the mouse model of Rhesus rotavirus (RRV)-induced biliary atresia have linked the importance of effector lymphocytes to the pathogenesis of extrahepatic bile duct (EHBD) injury and obstruction in experimental biliary atresia; however, studies of the progressive liver injury have bee...

2013
O. E. O'Sullivan D. Crosby B. Byrne C. Regan

Biliary atresia is a rare idiopathic neonatal cholestatic disease characterized by the destruction of both the intra- and extrahepatic biliary ducts. As the disease is progressive all cases will develop portal fibrosis, cirrhosis, and portal hypertension with the sequelae of varices, jaundice, and eventually liver failure requiring a transplant. Survival rates have improved considerably with ma...

Journal: :Comparative Hepatology 2004
Grant A Ramm Anita C Hoskins Sonia A Greco Tamara N Pereira Peter J Lewindon

Neonatal Cholestatic Liver Diseases Cholestatic liver disease in children occurs as a result of either an alteration in hepatocyte bile formation or disruption of bile flow out of the hepatocyte through intrahepatic bile ductules or extrahepatic bile ducts [1]. Liver disease usually appears within the first few weeks following birth. A large number of disorders exhibit cholestatic jaundice in n...

Journal: :The Journal of infectious diseases 1996
M Riepenhoff-Talty V Gouvea M J Evans L Svensson E Hoffenberg R J Sokol I Uhnoo S J Greenberg K Schäkel G Zhaori J Fitzgerald S Chong M el-Yousef A Nemeth M Brown D Piccoli J Hyams D Ruffin T Rossi

The purpose of this retrospective study was to examine liver tissue from patients with cholestatic disease for the presence of group C rotavirus RNA. The reverse transcriptase-polymerase chain reaction (PCR) for genes 5 and 6 was used, and the PCR products were subjected to liquid hybridization with a 32P-labeled probe. A second amplification with nested primers was also used. Samples from 32 s...

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