Serous tumours of the testis and paratestis are rare, with fewer than 50 cases reported in the literature. The majority of the reported cases have been borderline serous tumours, and these tend not to recur or metastasize. Conversely, serous carcinomas can metastasize but this is often a late event. The presence of invasion in an otherwise borderline tumour has also been associated with the dev...

We performed an integrated genomic, transcriptomic and proteomic characterization of 373 endometrial carcinomas using array-andsequencing-based technologies.Uterine serous tumoursand 25%ofhigh-gradeendometrioid tumours had extensive copy number alterations, few DNA methylation changes, low oestrogen receptor/progesterone receptor levels, and frequentTP53mutations.Most endometrioid tumourshad fe...

Retropharyngeal lipomas are rare tumours that are usually asymptomatic until they reach a large size. The definitive treatment is surgical excision. Since the tumours are typically large at the time of presentation, extensive surgery for complete clearance of the lipoma from the retropharyngeal and parapharyngeal regions is to be expected. Transoral excision is typically indicated for small ret...

Due to recent improvements of safety conditions for therapeutic devices, electrocautery is being considered with renewed interest in the field of therapeutic bronchoscopy. The efficiency of this technique for destructing intraluminal tumours is well documented and makes it an attractive alternative to Yttrium aluminium garnet (YAG) laser photo-coagulation. Little is known, however, about the mo...

BACKGROUND Bulky endobronchial tumours in patients with lung cancer are difficult to treat. Brachytherapy and photodynamic therapy (PDT) are variably effective, and the combination of these treatments is not often recommended. However, cell culture studies and animal studies indicate a possible synergistic effect of combining PDT with ionising radiation. We assessed the safety and effectiveness...

Background: Complication rates reported for contemporary knee reconstruction limb salvage surgery (LSS), an alternative to amputation patients with bone tumours of the proximal tibia and distal femur, have not been extensively explored in China. Objective: Functional outcomes, survival, prosthesis failure, and complication rates were investigated in Chinese patients with malignant or aggressive...

BACKGROUND Primary bone lymphomas are very rare. The diagnosis is based on a histopathological examination and imaging studies where other disease foci should be excluded. The lymphomas are most often found in the axial skeleton, pelvis, femur and humerus. The tumour causes extensive lytic bone destruction with soft tissue infiltration. Surgical treatment is currently not used routinely. The ai...

Abstract BACKGROUND Malignant paediatric nervous system tumours, such as medulloblastoma, ATRT and high-risk neuroblastoma commonly harbour tumour cells with stem-like features which are highly tumorigenic resistant to conventional therapies. These tumours can exhibit high lethality may result in severe sequelae that significantly affect patients' quality of life. Oncolytic virotherapy exploits...

We describe a patient with extensive ischaemic necrosis of the ileum as a result of elastic vascular sclerosis (EVS). A 2 cm carcinoid tumour was located nearby with microscopic evidence of spread to regional lymph nodes. Severe intestinal ischaemia caused by carcinoid associated EVS may be the presenting feature of small carcinoid tumours resulting in their early diagnosis.

OBJECTIVES To determine whether variations in the expression of tumour related antigens can predict the origin of tumours. DESIGN Immunohistological study of tumour marker expression in primary adenocarcinomas and respective metastatic deposits. Antibodies to the following tumour markers were used: polymorphic epithelial mucin (NCRC-11 and SM3), carcinoembryonic antigen, carcinoembryonic anti...