The aim of the current investigation was to evaluate the fracture resistance of one-piece zirconia oral implants with and without all-ceramic incisor crowns after long-term thermomechanical cycling. A total of 48 implants were evaluated. The groups with crowns (C, 24 samples) and without crowns (N, 24 samples) were subdivided according to the loading protocol, resulting in three groups of 8 sam...

The isolation of N10 formylfolic acid' from natural materials has been reported by several groups of workers (Rauen et al., 1952; Rauen and Jaenicke, 1953; Greenberg, 1954a; Silverman et al., 1954). It was concluded that the compound had been derived either from the degradation of a labile intermediate involved in the conversion of a bound (microbiologically inactive) form of folic acid in live...

Educational solutions for allied health professionals (AHP’s) need to stimulate problem-solving skills although AHP’s seldom have the opportunity to develop these skills in a paediatric environment prior to registration. Computer aided learning (CAL) has become an established educational option with a growing body of literature detailing positive CAL introduction within HC education across many...

The first polynomial-time algorithm to approximate (with arbitrary precision) the permanent of a non-negative matrix was presented by Jerrum, Sinclair and Vigoda. They designed a simulated annealing algorithm with a running time of O∗(n26) for 0/1 matrices. Subsequently, they improved their analysis, resulting in a O∗(n10) time algorithm. We present a O∗(n7) time algorithm. Our improvement come...

We prove polynomial upper bounds of geometric Ramsey numbers of pathwidth2 outerplanar triangulations in both convex and general cases. We also prove that the geometric Ramsey numbers of the ladder graph on 2n vertices are bounded by O(n3) and O(n10), in the convex and general case, respectively. We then apply similar methods to prove an nO(log(n)) upper bound on the Ramsey number of a path wit...

The acidities of multiple sites in the purine nucleobase adenine (1) and adenine alkyl derivatives 9-ethyladenine (2), 3-methyladenine (3), 1-methyladenine (4), and N,N-dimethyladenine (5) have been investigated for the first time, using computational and experimental methods to provide an understanding of adenine reactivity. We have previously measured two acidic sites on adenine, with the N9 ...

Biochemical and biological studies have been carried out with 2-desamino-2-methylaminopterin (dmAMT), which inhibits tumor cell growth in culture but is only a weak inhibitor of dihydrofolate reductase (DHFR). Since it was possible that the species responsible for growth inhibition are polyglutamylated metabolites, the di-, tri-, and tetraglutamates of dmAMT were synthesized and tested as inhib...